PMID- 15651318
OWN - NLM
STAT- MEDLINE
DCOM- 20050304
LR  - 20061115
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 44
IP  - 11
DP  - 2004 Nov
TI  - [Frontotemporal dementia and frontotemporal degeneration--how to define?].
PG  - 872-4
AB  - The term of the frontotemporal dementia was first proposed by Lund and Manchester 
      group in 1994, but the definition of frontotemporal dementia has been still 
      controversial. Frontotemporal dementia is caused by several diseases which have 
      fronto-temporal atrophy. The diseases are collectedly designated as frontotempoal 
      degeneration. The frontotemporal degeneration encompasses several diseases such 
      as Pick disease (frontotemporal degeneration with Pick bodies) and frontotemporal 
      degeneration with ubiquitin-positive inclusions and frontotemporal degeneration 
      (no inclusion bodies are observed). Pick bodies are consisted of abnormally 
      phosphorylated tau protein. The recent discoveries of tau mutations in 
      frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) 
      suggest important role of tau abnormalities in the disease mechanism. The 
      frontotemporal degeneration has also another clinical phenotype such as slowly 
      progressive aphasia. Slowly progressive aphasia has subtypes of non-fluent 
      aphasia and semantic aphasia. Some patients with corticobasal degeneration or 
      progressive supranuclear palsy also reveal the clinical pictures of 
      frontotemporal dementia or slowly progressive aphasia and should be considered as 
      differential diagnosis in the patients with frontotemporal dementia or slowy 
      progressive aphasia.
FAU - Mori, Hideo
AU  - Mori H
AD  - Department of Neurology, Juntendo University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - *Dementia
MH  - Humans
MH  - Pick Disease of the Brain
RF  - 5
EDAT- 2005/01/18 09:00
MHDA- 2005/03/05 09:00
CRDT- 2005/01/18 09:00
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/03/05 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2004 Nov;44(11):872-4.