PMID- 15652982
OWN - NLM
STAT- MEDLINE
DCOM- 20050511
LR  - 20140325
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 130
IP  - 4
DP  - 2005
TI  - Dissociation of the effect of spatial behaviors on the phosphorylation of 
      cAMP-response element binding protein (CREB) within the nucleus accumbens.
PG  - 833-42
AB  - Several studies have reported a role for the nucleus accumbens (NAcc) in learning 
      and synaptic plasticity. Many of them suggest that the NAcc is involved in 
      translating cortico-limbic information to the motor system mediating spatial 
      learning and memory processes. Previous studies from our laboratory have shown 
      that protein kinase C is activated following training in a food search spatial 
      learning task. The present study further characterizes the molecular substrates 
      associated with NAcc-dependent spatial behavior. The cyclic AMP-response element 
      binding protein (CREB), a transcription factor implicated in the formation of 
      long-term memory, was studied in the NAcc following spatial training in a food 
      search spatial learning task. Western blots were performed to detect 
      phosphorylated (activated) and total CREB protein levels. Our results show that 
      CREB is significantly phosphorylated in the NAcc 48 h after habituation and at 5 
      min and 1 h after the first spatial training session in comparison with the naive 
      animals that remained in their home cages. Since published data show that NAcc 
      plays a role in novelty detection and reactivity, we conducted further 
      experiments in order to dissociate the effect on CREB phosphorylation and 
      expression of spatial novelty (single exposure), exploration, and spatial 
      learning in the food search apparatus. Results show that CREB phosphorylation is 
      significantly increased 48 h after exposure to a novel environment. The present 
      study suggests that CREB phosphorylation observed in the NAcc during habituation 
      and spatial training may be mainly triggered by detection of spatial novelty.
FAU - Alvarez-Jaimes, L
AU  - Alvarez-Jaimes L
AD  - University of Puerto Rico, Rio Piedras Campus, Department of Biology, P.O. Box 
      23360, San Juan, Puerto Rico 00931-3360.
FAU - Centeno-Gonzalez, M
AU  - Centeno-Gonzalez M
FAU - Feliciano-Rivera, M
AU  - Feliciano-Rivera M
FAU - Maldonado-Vlaar, C S
AU  - Maldonado-Vlaar CS
LA  - eng
GR  - 1 GM5S06GM0813/GM/NIGMS NIH HHS/United States
GR  - P20 RR15565 02/RR/NCRR NIH HHS/United States
GR  - R25 GM6-1151-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
SB  - IM
MH  - Animals
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Exploratory Behavior/*physiology
MH  - Habituation, Psychophysiologic/physiology
MH  - Learning/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Neuronal Plasticity/physiology
MH  - Nucleus Accumbens/*metabolism
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reaction Time/physiology
MH  - Reward
MH  - Space Perception/*physiology
MH  - Spatial Behavior/*physiology
MH  - Time Factors
EDAT- 2005/01/18 09:00
MHDA- 2005/05/12 09:00
CRDT- 2005/01/18 09:00
PHST- 2004/09/21 00:00 [accepted]
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/05/12 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
AID - S0306-4522(04)00870-X [pii]
AID - 10.1016/j.neuroscience.2004.09.045 [doi]
PST - ppublish
SO  - Neuroscience. 2005;130(4):833-42. doi: 10.1016/j.neuroscience.2004.09.045.