PMID- 15653417
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20061115
IS  - 1386-6532 (Print)
IS  - 1386-6532 (Linking)
VI  - 32
IP  - 2
DP  - 2005 Feb
TI  - Human leukocyte antigen phenotypes and hepatitis C viral load.
PG  - 144-50
AB  - BACKGROUND: After hepatitis C virus (HCV) infection, 55% to 85% of patients 
      become chronic carriers. HCV-RNA could be detected in the sera of these patients 
      though the viral load varies. Various factors may be involved in determining the 
      viral load. OBJECTIVES: In this study, we want to investigate the relationship 
      between human leukocyte antigen phenotypes and hepatitis C viral load. STUDY 
      DESIGN: One hundred and sixty HCV-RNA positive subjects were investigated in this 
      study. RESULTS: We have analyzed 160 HCV-RNA positive subjects and found that 
      lower HCV viral load is significantly associated with HBsAg-positivity (P = 
      0.017) but not age, gender, or mixed infection (infection with different HCV 
      genotypes). One hundred and fifty-four HBsAg-negative subjects were further 
      analyzed to explore the relationship between human leukocyte antigen (HLA) 
      phenotypes and HCV viral load. Subjects with certain HLA alleles (A*34, B*56, 
      DRB1*1502) have significantly lower viral load than those without these alleles 
      (P = 0.0074, 0.0039 and 0.016, respectively) while those with HLA-B*4001 have 
      significantly higher viral load (P = 0.0026). Furthermore, lower viral load was 
      significantly associated with HLA-DRB1 heterozygosity in subjects with HLA-B 
      heterozygosity (P = 0.048). CONCLUSIONS: Our data suggests a role for host 
      immunogenetic factors in determining viral load during HCV infection.
FAU - Wang, Li-Yu
AU  - Wang LY
AD  - Graduate Institute of Aboriginal Health, Tzu Chi University, Hualien, Taiwan.
FAU - Lin, Hans Hsienhong
AU  - Lin HH
FAU - Lee, Tsung-Dao
AU  - Lee TD
FAU - Wu, Ya-Fang
AU  - Wu YF
FAU - Hu, Chi-Tan
AU  - Hu CT
FAU - Cheng, Mu-Liang
AU  - Cheng ML
FAU - Lo, Shih-Yen
AU  - Lo SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Clin Virol
JT  - Journal of clinical virology : the official publication of the Pan American 
      Society for Clinical Virology
JID - 9815671
RN  - 0 (HLA Antigens)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Aged
MH  - Female
MH  - HLA Antigens/*classification
MH  - Hepacivirus/classification/genetics/*physiology
MH  - Hepatitis C/virology
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - Oligonucleotide Probes
MH  - Phenotype
MH  - RNA, Viral/blood
MH  - *Viral Load
EDAT- 2005/01/18 09:00
MHDA- 2005/03/23 09:00
CRDT- 2005/01/18 09:00
PHST- 2004/04/26 00:00 [revised]
PHST- 2004/05/18 00:00 [accepted]
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
AID - S1386653204001647 [pii]
AID - 10.1016/j.jcv.2004.05.011 [doi]
PST - ppublish
SO  - J Clin Virol. 2005 Feb;32(2):144-50. doi: 10.1016/j.jcv.2004.05.011.