PMID- 15653504
OWN - NLM
STAT- MEDLINE
DCOM- 20050202
LR  - 20171116
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 307
IP  - 5707
DP  - 2005 Jan 14
TI  - CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial 
      clearance.
PG  - 254-8
AB  - Dendritic cells (DCs) and macrophages are critical to innate and adaptive 
      immunity to the intestinal bacterial microbiota. Here, we identify a 
      myeloid-derived mucosal DC in mice, which populates the entire lamina propria of 
      the small intestine. Lamina propria DCs were found to depend on the chemokine 
      receptor CX3CR1 to form transepithelial dendrites, which enable the cells to 
      directly sample luminal antigens. CX3CR1 was also found to control the clearance 
      of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which 
      control host interactions of specialized DCs with commensal and pathogenic 
      bacteria, may regulate immunological tolerance and inflammation.
FAU - Niess, Jan Hendrik
AU  - Niess JH
AD  - Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 
      55 Fruit Street, Boston, MA 02114, USA.
FAU - Brand, Stephan
AU  - Brand S
FAU - Gu, Xiubin
AU  - Gu X
FAU - Landsman, Limor
AU  - Landsman L
FAU - Jung, Steffen
AU  - Jung S
FAU - McCormick, Beth A
AU  - McCormick BA
FAU - Vyas, Jatin M
AU  - Vyas JM
FAU - Boes, Marianne
AU  - Boes M
FAU - Ploegh, Hidde L
AU  - Ploegh HL
FAU - Fox, James G
AU  - Fox JG
FAU - Littman, Dan R
AU  - Littman DR
FAU - Reinecker, Hans-Christian
AU  - Reinecker HC
LA  - eng
GR  - AI33856/AI/NIAID NIH HHS/United States
GR  - DK33506/DK/NIDDK NIH HHS/United States
GR  - DK54427/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Chemokines, CX3C)
RN  - 0 (Cx3cl1 protein, mouse)
RN  - 0 (Cx3cr1 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Chemokine)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Animals
MH  - CX3C Chemokine Receptor 1
MH  - Chemokine CX3CL1
MH  - Chemokines, CX3C/metabolism
MH  - Dendritic Cells/cytology/*immunology/microbiology
MH  - Escherichia coli/*immunology/isolation & purification
MH  - Gene Deletion
MH  - Green Fluorescent Proteins/metabolism
MH  - Ileum/cytology/immunology
MH  - *Immunity, Mucosal
MH  - Intestinal Mucosa/*immunology/microbiology
MH  - Intestine, Small/immunology/microbiology
MH  - Lymphoid Tissue/cytology/immunology
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Peyer's Patches/immunology/microbiology
MH  - Phagocytosis
MH  - Receptors, Chemokine/genetics/metabolism/*physiology
MH  - Salmonella Infections, Animal/*immunology/microbiology
MH  - Salmonella typhimurium/*immunology/isolation & purification
EDAT- 2005/01/18 09:00
MHDA- 2005/02/03 09:00
CRDT- 2005/01/18 09:00
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
AID - 307/5707/254 [pii]
AID - 10.1126/science.1102901 [doi]
PST - ppublish
SO  - Science. 2005 Jan 14;307(5707):254-8. doi: 10.1126/science.1102901.