PMID- 15653983
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20220331
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 127
IP  - 1
DP  - 2005 Jan
TI  - An assessment of back pain and the prevalence of sacroiliitis in sarcoidosis.
PG  - 192-6
AB  - OBJECTIVES: Sarcoidosis is a chronic granulomatous multisystem disease in which 
      arthritis is relatively common. Arthritis of the sacroiliac joints (sacroiliitis) 
      has been described in sarcoidosis but is thought to be rare. The objective of 
      this study was to determine the prevalence of sacroiliitis in a secondary-care 
      population of patients with sarcoidosis. METHODS: Patients attending a specialist 
      secondary-care sarcoidosis clinic underwent evaluation of spinal symptoms using a 
      standard back pain questionnaire, examination of spinal mobility, and laboratory 
      measurements of erythrocyte sedimentation rate, C-reactive protein, serum 
      angiotensin-converting enzyme, and neopterin/creatinine ratio. Tissue typing for 
      the presence of the human leukocyte antigen (HLA)-B27 allele was undertaken. 
      Radiographs of the sacroiliac joints were obtained in each patient and reviewed 
      independently by two observers; a further observer reviewed disputed radiographs. 
      RESULTS: Sixty-one patients completed the assessments (80.3% of all patients 
      invited to participate). Forty-nine of 61 patients (80.3%) reported having back 
      pain at some point in their lives. Thirty-one of 61 patients (50.8%) had a score 
      on the back pain questionnaire suggestive of inflammatory spinal disease, but 
      only 3 of these patients had erosive damage of the sacroiliac joints on 
      radiography indicating sacroiliitis. One further patient had erosive damage on 
      radiography, making a total of four individuals with evidence of sacroiliitis, a 
      prevalence of 6.6%. Four patients (one patient with sacroiliitis) were positive 
      for HLA-B27. The back pain questionnaire had a sensitivity of 75% and a 
      specificity of 51% for sacroiliitis in this population. CONCLUSION: The 
      prevalence of spondyloarthropathy in the normal population has been estimated to 
      be 1.9%. In the sarcoid population studied the prevalence was 6.6% suggesting a 
      possible association between these two conditions. The standard back pain 
      questionnaire for the identification of inflammatory spinal disease had a low 
      sensitivity and specificity in this population.
FAU - Erb, Nicola
AU  - Erb N
AD  - Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Dudley, West 
      Midlands, UK.
FAU - Cushley, Michael J
AU  - Cushley MJ
FAU - Kassimos, Dimitrios G
AU  - Kassimos DG
FAU - Shave, Ruth M
AU  - Shave RM
FAU - Kitas, George D
AU  - Kitas GD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Arthritis/blood/*epidemiology
MH  - Back Pain/blood/epidemiology
MH  - Comorbidity
MH  - Female
MH  - HLA-B27 Antigen/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Sarcoidosis/blood/*epidemiology
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires
EDAT- 2005/01/18 09:00
MHDA- 2005/02/23 09:00
CRDT- 2005/01/18 09:00
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
AID - S0012-3692(15)32392-8 [pii]
AID - 10.1378/chest.127.1.192 [doi]
PST - ppublish
SO  - Chest. 2005 Jan;127(1):192-6. doi: 10.1378/chest.127.1.192.