PMID- 15654341
OWN - NLM
STAT- MEDLINE
DCOM- 20050301
LR  - 20081121
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 6
IP  - 2
DP  - 2005 Feb
TI  - Inflammatory mediators are insufficient for full dendritic cell activation and 
      promote expansion of CD4+ T cell populations lacking helper function.
PG  - 163-70
AB  - Dendritic cells (DCs) can be activated directly by triggering of receptors for 
      pathogens or, indirectly, by exposure to inflammatory signals. It remains 
      unclear, however, whether the two pathways result in qualitatively similar DCs or 
      lead to equivalent adaptive immune responses. Here we report that indirect 
      activation by inflammatory mediators generated DCs that supported CD4(+) T cell 
      clonal expansion but failed to direct T helper cell differentiation. In contrast, 
      exposure to pathogen components resulted in fully activated DCs that promoted T 
      helper responses. These results indicate that inflammation cannot substitute for 
      contact with pathogen components in DC activation and suggest that the function 
      of pattern recognition by DCs is to couple the quality of the adaptive immune 
      response to the nature of the pathogen.
FAU - Sporri, Roman
AU  - Sporri R
AD  - Immunobiology Laboratory, Cancer Research UK, London Research Institute, London 
      WC2A 3PX, UK.
FAU - Reis e Sousa, Caetano
AU  - Reis e Sousa C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050116
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Inflammation Mediators)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
CIN - Nat Immunol. 2005 Feb;6(2):125-6. PMID: 15662437
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - CD4-Positive T-Lymphocytes/*cytology/*immunology/metabolism
MH  - Cell Differentiation/*immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/*cytology/*immunology/metabolism
MH  - Inflammation Mediators/*immunology/metabolism
MH  - Interferon-gamma/metabolism
MH  - Interleukin-12/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - T-Lymphocytes, Helper-Inducer/cytology/immunology/metabolism
EDAT- 2005/01/18 09:00
MHDA- 2005/03/02 09:00
CRDT- 2005/01/18 09:00
PHST- 2004/10/15 00:00 [received]
PHST- 2004/12/20 00:00 [accepted]
PHST- 2005/01/18 09:00 [pubmed]
PHST- 2005/03/02 09:00 [medline]
PHST- 2005/01/18 09:00 [entrez]
AID - ni1162 [pii]
AID - 10.1038/ni1162 [doi]
PST - ppublish
SO  - Nat Immunol. 2005 Feb;6(2):163-70. doi: 10.1038/ni1162. Epub 2005 Jan 16.