PMID- 15654960
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20220318
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 124
IP  - 1
DP  - 2005 Jan
TI  - The major psoriasis susceptibility locus PSORS1 is not a risk factor for 
      late-onset psoriasis.
PG  - 103-6
AB  - PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies 
      within an approximately 200 kb segment of the major histocompatibility complex on 
      chromosome 6p21.3. Alleles of candidate genes in this region including human 
      leukocyte antigen (HLA)-C, alpha-helical coiled coil rod (HCR), and 
      corneodesmosin (CDSN) show association with early-onset PV. Late-onset psoriasis 
      (LOP) is defined as a disease with onset after 40 y of age and is typically 
      sporadic. We assessed the role of PSORS1 in genetic susceptibility to LOP. 
      Genotyping for HLA-C alleles and seven single nucleotide polymorphisms (SNP) 
      within the genes HCR and CDSN was performed in LOP (n=145) and normal controls 
      (n=309). Statistical analysis of allelic frequencies included calculation of odds 
      ratio and chi2 comparisons. LOP demonstrated only a weak association to PSORS1 
      alleles HLA-Cw*6 (p=0.037), CDSN*5 (p=0.041), HCR*WC (p=0.013), and HCR SNP +325 
      (p=0.038). Patients with age of onset for psoriasis of 50 y or above provided no 
      evidence of association with any of these alleles. These data suggest that the 
      study cohort may include a number of subjects who harbor PSORS1 predisposition to 
      early-onset psoriasis and yet do not present with disease by the age of 40 y. 
      Thus this study demonstrates that PSORS1 is not a major inherited risk factor in 
      the pathogenesis of LOP. These data suggest that the exclusion of LOP subjects 
      from case-control studies will aid further delineation of the PSORS1 locus. 
      Future genome-wide studies will be required to identify loci conferring risk for 
      late-onset disease.
FAU - Allen, Michael Hugh
AU  - Allen MH
AD  - St John's Institute of Dermatology, Kings College London, London, UK. 
      michael.allen@kcl.ac.uk
FAU - Ameen, Hahreen
AU  - Ameen H
FAU - Veal, Colin
AU  - Veal C
FAU - Evans, Julie
AU  - Evans J
FAU - Ramrakha-Jones, V S
AU  - Ramrakha-Jones VS
FAU - Marsland, A M
AU  - Marsland AM
FAU - Burden, A David
AU  - Burden AD
FAU - Griffiths, C E M
AU  - Griffiths CE
FAU - Trembath, Richard C
AU  - Trembath RC
FAU - Barker, Jonathan N W N
AU  - Barker JN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosomes, Human, Pair 6
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*epidemiology/*genetics
MH  - Risk Factors
EDAT- 2005/01/19 09:00
MHDA- 2005/03/08 09:00
CRDT- 2005/01/19 09:00
PHST- 2005/01/19 09:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2005/01/19 09:00 [entrez]
AID - S0022-202X(15)32118-7 [pii]
AID - 10.1111/j.0022-202X.2004.23511.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 2005 Jan;124(1):103-6. doi: 10.1111/j.0022-202X.2004.23511.x.