PMID- 1565570
OWN - NLM
STAT- MEDLINE
DCOM- 19920521
LR  - 20161123
IS  - 0029-5566 (Print)
IS  - 0029-5566 (Linking)
VI  - 31
IP  - 2
DP  - 1992 Mar
TI  - [L-18F-dopa-PET in Parkinson-plus syndromes for the detection of a disordered 
      presynaptic dopaminergic function].
PG  - 43-7
AB  - PET examinations using L-18F-DOPA were performed on 14 patients with 
      Parkinsonism-plus syndromes (PPLUS). A rate constant Ki was calculated by a 
      graphical method using an arterial input function. Sequential PET images were 
      obtained and no specific activity was measured both in cortical and cerebellar 
      background regions. These results were compared with those in 20 normal controls 
      and tested for intra- and interobserver variability. All patients with PPLUS 
      showed reduced Ki values with a mean of 0.154 (ml/striatum/min), whereas controls 
      exhibited Ki values with a mean of 0.690 (ml/striatum/min) using cortical 
      background regions. The correlation coefficient was calculated to be r = 0.973 
      for the intraobserver variability and r = 0.879 for the interobserver variability 
      in controls, and r = 0.989 or = 0.973 in PPLUS, resp. There was no significant 
      difference in the Ki values for cortical and cerebellar background regions (p = 
      0.1). PET examinations using L-18F-DOPA can reliably assess the extent of 
      nigrostriatal degeneration in vivo. Since this radiotracer binds irreversibly 
      within the striatum PET examinations allow the quantification of a disturbed 
      dopaminergic function which is observer-independent.
FAU - Cordes, M
AU  - Cordes M
AD  - Neurodegenerative Disorders Centre, Faculty of Medicine, University Hospital, 
      University of British Columbia, Vancouver, Canada.
FAU - Snow, B J
AU  - Snow BJ
FAU - Takahashi, H
AU  - Takahashi H
FAU - Schofield, P
AU  - Schofield P
FAU - Cooper, S
AU  - Cooper S
FAU - Sossi, V
AU  - Sossi V
FAU - Morrison, S
AU  - Morrison S
FAU - Calne, D B
AU  - Calne DB
LA  - ger
PT  - Journal Article
TT  - L-18F-DOPA-PET bei Parkinson-Plus-Syndromen zum Nachweis einer gestorten 
      prasynaptischen dopaminergen Funktion.
PL  - Germany
TA  - Nuklearmedizin
JT  - Nuklearmedizin. Nuclear medicine
JID - 7609387
RN  - 0 (Fluorine Radioisotopes)
RN  - 46627O600J (Levodopa)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aged
MH  - Dopamine/*physiology
MH  - Female
MH  - Fluorine Radioisotopes
MH  - Humans
MH  - *Levodopa
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnostic imaging/physiopathology
MH  - Shy-Drager Syndrome/*diagnostic imaging/physiopathology
MH  - Supranuclear Palsy, Progressive/*diagnostic imaging/physiopathology
MH  - *Tomography, Emission-Computed
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
PST - ppublish
SO  - Nuklearmedizin. 1992 Mar;31(2):43-7.