PMID- 15655774
OWN - NLM
STAT- MEDLINE
DCOM- 20050308
LR  - 20111117
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 191
IP  - 4
DP  - 2005 Feb 15
TI  - Human leukocyte antigen class II alleles and rubella-specific humoral and 
      cell-mediated immunity following measles-mumps-rubella-II vaccination.
PG  - 515-9
AB  - We examined associations between human leukocyte antigen (HLA) class II genes and 
      both rubella-specific immunoglobulin G antibodies and lymphoproliferative 
      responses after measles-mumps-rubella-II (MMR-II) vaccination, in a 
      population-based sample of 346 schoolchildren. The DPB1*0301, DPB1*0401, 
      DPB1*1301, and DPB1*1501 alleles were significantly associated with rubella 
      vaccine-induced antibodies. Alleles suggestive of being positively associated 
      with rubella-specific lymphoproliferative stimulation indices were DPB1*0301, 
      DQB1*0501, DRB1*0101, and DRB1*1104. Conversely, the DPB1*0401, DPB1*1001, 
      DPB1*1101, DQB1*0202, and DRB1*0701 alleles were negatively associated with 
      rubella-specific lymphoproliferation. This study of HLA class II-restricted 
      humoral and cellular immune responses to rubella provides significant insight 
      into mechanisms of vaccine response and new vaccine development.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
AD  - Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 
      55905, USA.
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - AI 33144/AI/NIAID NIH HHS/United States
GR  - AI 48793/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050114
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Measles-Mumps-Rubella Vaccine)
RN  - 0 (rubella antibodies)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Female
MH  - *Genes, MHC Class II
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - *Lymphocyte Activation
MH  - Male
MH  - Measles-Mumps-Rubella Vaccine/*immunology
MH  - Rubella virus/*immunology
MH  - Vaccination
EDAT- 2005/01/19 09:00
MHDA- 2005/03/09 09:00
CRDT- 2005/01/19 09:00
PHST- 2004/04/01 00:00 [received]
PHST- 2004/09/07 00:00 [accepted]
PHST- 2005/01/19 09:00 [pubmed]
PHST- 2005/03/09 09:00 [medline]
PHST- 2005/01/19 09:00 [entrez]
AID - JID32806 [pii]
AID - 10.1086/427558 [doi]
PST - ppublish
SO  - J Infect Dis. 2005 Feb 15;191(4):515-9. doi: 10.1086/427558. Epub 2005 Jan 14.