PMID- 15656804
OWN - NLM
STAT- MEDLINE
DCOM- 20050414
LR  - 20071115
IS  - 0007-0963 (Print)
IS  - 0007-0963 (Linking)
VI  - 152
IP  - 1
DP  - 2005 Jan
TI  - Clinicopathological features of cutaneous lesions of adult T-cell leukaemia/ 
      lymphoma.
PG  - 76-81
AB  - BACKGROUND: Adult T-cell leukaemia/lymphoma (ATLL) is a human malignancy 
      associated with human T-cell leukaemia virus type I (HTLV-I). ATLL frequently 
      involves the skin. OBJECTIVES: To correlate the clinicopathological features and 
      prognosis in patients with ATLL and cutaneous lesions. METHODS: We examined the 
      HTLV-I proviral state and the clinicopathological features of the cutaneous 
      lesions in 80 patients with serum anti-ATL antibody, to clarify the correlation 
      between macroscopic/histopathological findings and prognosis. Southern blot 
      analysis was performed in all cases to detect monoclonal HTLV-I proviral DNA 
      integration. RESULTS: The cutaneous lesions of 46 patients were positive for 
      proviral DNA integration. The median survival time of patients with monoclonal 
      proviral DNA integration in cutaneous lesions was 14 months, which was markedly 
      shorter than that of patients negative for proviral DNA integration (72 months). 
      Of the 46 patients with proviral DNA, 21 had solitary or multiple red nodules 
      (including three with subcutaneous induration), eight had multiple red papules 
      and 17 had erythema. Patients with papules and nodules had poorer prognosis than 
      those with erythema. Histopathologically, the prognosis was poorer in patients 
      with nodular or diffuse infiltration of medium-sized to large lymphoma cells, 
      compared with those with perivascular infiltration of small to medium-sized 
      lymphoma cells. CONCLUSIONS: Our results show a close correlation between 
      clinicopathological features of HTLV-I-associated cutaneous lesions and 
      prognosis.
FAU - Yamaguchi, T
AU  - Yamaguchi T
AD  - Department of Pathology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, 
      Jonan-ku, Fukuoka 814-0189, Japan. yamaguchi@minf.med.fukuoka-u.ac.jp
FAU - Ohshima, K
AU  - Ohshima K
FAU - Karube, K
AU  - Karube K
FAU - Tutiya, T
AU  - Tutiya T
FAU - Kawano, R
AU  - Kawano R
FAU - Suefuji, H
AU  - Suefuji H
FAU - Shimizu, A
AU  - Shimizu A
FAU - Nakayama, J
AU  - Nakayama J
FAU - Suzumiya, J
AU  - Suzumiya J
FAU - Moroi, Y
AU  - Moroi Y
FAU - Urabe, K
AU  - Urabe K
FAU - Furue, M
AU  - Furue M
FAU - Koga, T
AU  - Koga T
FAU - Kikuchi, M
AU  - Kikuchi M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - DNA, Viral/analysis
MH  - Female
MH  - Human T-lymphotropic virus 1/isolation & purification
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/immunology/*pathology/virology
MH  - *Leukemic Infiltration
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proviruses/isolation & purification
MH  - Skin/immunology/*pathology/virology
MH  - Survival Analysis
MH  - Virus Integration
EDAT- 2005/01/20 09:00
MHDA- 2005/04/15 09:00
CRDT- 2005/01/20 09:00
PHST- 2005/01/20 09:00 [pubmed]
PHST- 2005/04/15 09:00 [medline]
PHST- 2005/01/20 09:00 [entrez]
AID - BJD6274 [pii]
AID - 10.1111/j.1365-2133.2004.06274.x [doi]
PST - ppublish
SO  - Br J Dermatol. 2005 Jan;152(1):76-81. doi: 10.1111/j.1365-2133.2004.06274.x.