PMID- 15657480
OWN - NLM
STAT- MEDLINE
DCOM- 20050419
LR  - 20051116
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 300
DP  - 2005
TI  - Nanomaterials of drug delivery systems for tissue regeneration.
PG  - 81-100
AB  - A new therapeutic trial aimed at assisting tissue regeneration at a body defect 
      in size too large for self-repair has recently begun. The objective is to 
      substitute the biological functions of damaged and injured organs by taking 
      advantage of cells. For successful tissue regeneration, it is absolutely 
      indispensable not only to have cells of high proliferation and differentiation 
      potential, but also to create an environment suitable for inducing regeneration. 
      Such creation can be artificially achieved only by providing various biomaterials 
      to promote cell proliferation and differentiation, such as cell scaffold and 
      growth factors. Growth factors are often required to promote tissue regeneration 
      because they can induce angiogenesis, which promotes a sufficient supply of 
      oxygen and nutrients to effectively maintain the biological functions of cells 
      transplanted for organ substitution. However, because of their poor in vivo 
      stability, the biological effects of growth factors cannot always be expected 
      unless these drug delivery systems (DDSs) are contrived. In this chapter, several 
      research approaches to tissue regeneration are reviewed to emphasize the 
      significance of biomaterials and DDS technologies in regenerative medicine.
FAU - Tabata, Yasuhiko
AU  - Tabata Y
AD  - Department of Biomaterials, Institute for Frontieer Medical Sciences, Kyoto 
      University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Growth Substances)
RN  - 0 (Hydrogels)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Animals
MH  - Bone Regeneration/drug effects
MH  - *Drug Delivery Systems
MH  - Gelatin
MH  - Growth Substances/*administration & dosage/pharmacology
MH  - Humans
MH  - *Hydrogels
MH  - Islets of Langerhans Transplantation
MH  - Mice
MH  - *Nanotechnology
MH  - Regeneration/*drug effects
MH  - Tissue Engineering
RF  - 39
EDAT- 2005/01/20 09:00
MHDA- 2005/04/20 09:00
CRDT- 2005/01/20 09:00
PHST- 2005/01/20 09:00 [pubmed]
PHST- 2005/04/20 09:00 [medline]
PHST- 2005/01/20 09:00 [entrez]
AID - 1-59259-858-7:081 [pii]
AID - 10.1385/1-59259-858-7:081 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2005;300:81-100. doi: 10.1385/1-59259-858-7:081.