PMID- 15658610
OWN - NLM
STAT- MEDLINE
DCOM- 20050511
LR  - 20191109
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 26
IP  - 4
DP  - 2004
TI  - Stachys riederi inhibits mast cell-mediated acute and chronic allergic reactions.
PG  - 621-30
AB  - The effect of aqueous extract of Stachys riederi var. japonica Miq. (Labiatae) 
      (SRAE) on the mast cell-mediated allergic and inflammatory reactions were 
      investigated. SRAE inhibited systemic allergic reaction induced by compound 
      48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) 
      activated by anti-dinitrophenyl (DNP) IgE. SRAE also dose-dependently inhibited 
      the histamine release from rat peritoneal mast cells (RPMC) activated by compound 
      48/80 or anti-DNP IgE. Moreover, SRAE inhibited the secretion of tumor necrosis 
      factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 
      13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells (HMC-1 
      cells). These results provide evidences that SRAE may be beneficial in the 
      treatment of acute and chronic allergic diseases.
FAU - Shin, Tae-Yong
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Jeonju, Jeonbuk, South Korea. 
      tyshin@woosuk.ac.kr
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Acute Disease
MH  - Anaphylaxis/drug therapy/immunology
MH  - Animals
MH  - Anti-Allergic Agents/pharmacology/*therapeutic use
MH  - Chronic Disease
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Hypersensitivity/*drug therapy/immunology
MH  - Mast Cells/*drug effects/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Peritoneum/cytology
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stachys/*chemistry
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 2005/01/22 09:00
MHDA- 2005/05/12 09:00
CRDT- 2005/01/22 09:00
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/05/12 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - 10.1081/iph-200042365 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2004;26(4):621-30. doi: 10.1081/iph-200042365.