PMID- 15659233
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20131121
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 92
IP  - 3
DP  - 2005 Feb
TI  - Differential effects of melanin concentrating hormone on the central dopaminergic 
      neurons induced by the cocaine- and amphetamine-regulated transcript peptide.
PG  - 637-46
AB  - Stimulatory effects of cocaine- and amphetamine-regulated transcript (CART) 
      peptide on central mesolimbic, nigrostriatal and mesocortical dopaminergic (DA) 
      neurons were examined in female Sprague-Dawley rats. We also determined the 
      different blocking effects of melanin concentrating hormone (MCH) on the 
      stimulation by CART peptide in central DA systems. Intracerebroventricular 
      administration of 1 microg CART peptide (55-102) produced increases in 
      3,4-dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens (NA) at 15 
      and 45 min, and in the striatum (ST) at 15 min, but not in the medial prefrontal 
      cortex (MPFC). We found that the agonist of alpha-melanocyte stimulating hormone 
      (alpha-MSH), MT II, at 10 microg had a stimulatory effect on the NA and ST DOPAC 
      levels similar to the CART peptide. In contrast, 1 microg MCH and the antagonist 
      of alpha-MSH, HS014, significantly decreased NA and ST DOPAC levels. However, 
      only MCH prevented the stimulatory effect of CART peptide on DOPAC levels in the 
      NA, but not in the ST. These results indicate that the stimulation of CART 
      peptide on central DA neurons is region-specific, and that this effect can be 
      blocked by MCH but not by the antagonist of alpha-MSH.
FAU - Yang, Shu-Chuan
AU  - Yang SC
AD  - Department of Nursing, Tzu Chi College of Technology, Hualien 970, Taiwan.
FAU - Shieh, Kun-Ruey
AU  - Shieh KR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (HS014 cyclic peptide)
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (Melanins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Pituitary Hormones)
RN  - 0 (Receptors, Melanocortin)
RN  - 0 
      (acetyl-norleucyl(4)-(aspartyl(5)-histidyl(6)-phenylalanyl(7)-arginyl(8)-tryptophyl(9)-lysyl(10))cyclo-alpha-MSH(4-10)amide)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein (55-102))
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 581-05-5 (alpha-MSH)
RN  - 67382-96-1 (melanin-concentrating hormone)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Dopamine/*metabolism
MH  - Drug Administration Routes
MH  - Female
MH  - Hypothalamic Hormones/*pharmacology
MH  - Melanins/*pharmacology
MH  - Neostriatum/drug effects/metabolism
MH  - Nerve Tissue Proteins
MH  - Neurons/*drug effects/*metabolism
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Ovariectomy
MH  - Peptide Fragments/antagonists & inhibitors/*pharmacology
MH  - Peptides, Cyclic/pharmacology
MH  - Pituitary Hormones/*pharmacology
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Melanocortin/agonists/antagonists & inhibitors
MH  - Time Factors
MH  - alpha-MSH/*analogs & derivatives/pharmacology
EDAT- 2005/01/22 09:00
MHDA- 2005/06/25 09:00
CRDT- 2005/01/22 09:00
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - JNC2896 [pii]
AID - 10.1111/j.1471-4159.2004.02896.x [doi]
PST - ppublish
SO  - J Neurochem. 2005 Feb;92(3):637-46. doi: 10.1111/j.1471-4159.2004.02896.x.