PMID- 15659264
OWN - NLM
STAT- MEDLINE
DCOM- 20050504
LR  - 20220716
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 5
IP  - 1
DP  - 2005 Jan
TI  - Role of regulatory dendritic cells in allergy and asthma.
PG  - 56-61
AB  - Dendritic cells (DCs) are the most efficient inducers of all immune responses, 
      and are capable of either inducing productive immunity or maintaining the state 
      of tolerance to self antigens and allergens. In this review, we summarize the 
      emerging literature on DCs, with emphasis on the regulatory function of DCs in 
      allergy and asthma. In particular, we summarize recent data regarding the 
      relationship between DC subsets and TH1, TH2, and regulatory T (TReg) cells. The 
      diverse functions of DCs have been attributed to distinct lineages of DCs, which 
      arise from common immature precursor cells that differentiate in response to 
      specific maturation-inducing or local microenvironment conditions. These subsets 
      of DCs induce different lineages of T cells, such as TH1, TH2, and TReg cells, 
      including Th1Reg and Th2Reg cells, which regulate allergic diseases and asthma. 
      Subsets of DCs regulate the induction of a variety of T-cell subtypes, which 
      suppress the development of allergy and asthma, thus providing anti-inflammatory 
      responses and protective immunity.
FAU - Akbari, Omid
AU  - Akbari O
AD  - Department of Pediatrics, Stanford University, Rm G309, 300 Pasteur Drive, 
      Stanford, CA 94305-5208, USA.
FAU - Umetsu, Dale T
AU  - Umetsu DT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
SB  - IM
MH  - Asthma/*immunology/prevention & control
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology/prevention & control
MH  - Hypersensitivity, Delayed/immunology/prevention & control
MH  - Hypersensitivity, Immediate/immunology/prevention & control
MH  - Immune Tolerance
MH  - Male
MH  - Sensitivity and Specificity
MH  - T-Lymphocyte Subsets/*immunology
MH  - Th1 Cells/physiology
MH  - Th2 Cells/immunology
RF  - 60
EDAT- 2005/01/22 09:00
MHDA- 2005/05/05 09:00
CRDT- 2005/01/22 09:00
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/05/05 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - 10.1007/s11882-005-0055-3 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2005 Jan;5(1):56-61. doi: 10.1007/s11882-005-0055-3.