PMID- 15659337
OWN - NLM
STAT- MEDLINE
DCOM- 20050622
LR  - 20220410
IS  - 1084-9521 (Print)
IS  - 1084-9521 (Linking)
VI  - 16
IP  - 1
DP  - 2005 Feb
TI  - mTOR, translational control and human disease.
PG  - 29-37
AB  - Many human diseases occur when the precise regulation of cell growth (cell 
      mass/size) and proliferation (rates of cell division) is compromised. This review 
      highlights those human disorders that occur as a result of inappropriate cellular 
      signal transduction through the mammalian target of rapamycin (mTOR), a major 
      pathway that coordinates proper cell growth and proliferation by regulating 
      ribosomal biogenesis and protein translation. Recent studies reveal that the 
      tuberous sclerosis complex (TSC)-1/2, PTEN, and LKB1 tumor suppressor proteins 
      tightly control mTOR. Loss of these tumor suppressors leads to an array of 
      hamartoma syndromes as a result of heightened mTOR signaling. Since mTOR plays a 
      pivotal role in maintaining proper cell size and growth, dysregulation of mTOR 
      signaling results in these benign tumor syndromes and an array of other human 
      disorders.
FAU - Tee, Andrew R
AU  - Tee AR
AD  - Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
FAU - Blenis, John
AU  - Blenis J
LA  - eng
GR  - CA46595/CA/NCI NIH HHS/United States
GR  - GM51405/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20041231
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Cell Proliferation
MH  - Disease/*etiology
MH  - Hamartoma/etiology
MH  - Humans
MH  - Hypertrophy, Left Ventricular/etiology
MH  - Neovascularization, Pathologic/etiology
MH  - *Protein Biosynthesis
MH  - Protein Kinases/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases
RF  - 89
EDAT- 2005/01/22 09:00
MHDA- 2005/06/23 09:00
CRDT- 2005/01/22 09:00
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/06/23 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - S1084-9521(04)00108-9 [pii]
AID - 10.1016/j.semcdb.2004.11.005 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2005 Feb;16(1):29-37. doi: 10.1016/j.semcdb.2004.11.005. 
      Epub 2004 Dec 31.