PMID- 15660663
OWN - NLM
STAT- MEDLINE
DCOM- 20050429
LR  - 20121115
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 4
IP  - 1
DP  - 2005 Feb
TI  - Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in 
      schizophrenia.
PG  - 2-9
AB  - Schizophrenia (SCZ) is a neuropsychiatric disorder that affects approximately 1% 
      of the general population. The human leukocyte antigen (HLA) system has been 
      implicated in several genetic studies of SCZ. The myelin oligodendrocyte 
      glycoprotein (MOG) gene, which is located close to the HLA region, is considered 
      a candidate for SCZ due to its association with white matter abnormalities and 
      its importance in mediating the complement cascade. Four polymorphisms in the MOG 
      gene (CA)n (TAAA)n, and two intronic polymorphisms, C1334T and C10991T, were 
      investigated for the possibility of association with SCZ using 111 SCZ proband 
      and their families. We examined the transmission of the alleles of each of these 
      polymorphisms with the transmission disequilibrium test. We did not observe 
      significant evidence for biased transmission of alleles at the (CA)n (chi2=2.430, 
      6 df, P=0.876) (TAAA)n (chi2=3.550, 5 df, P=0.616), C1334T (chi2=0.040, 1 df, 
      P=0.841) and C10991T (chi2=0.154, 1 df, P=0.695) polymorphisms. Overall haplotype 
      analysis using the TRANSMIT program was also not significant (chi2=7.954, 9 df, 
      P=0.539). Furthermore, our results comparing mean age at onset in the genotype 
      groups using the Kruskal-Wallis Test were not significant. Our case-control 
      analyses (182 cases age-, sex- and ethnicity-matched with healthy controls) and 
      combined z-score [(CA)n: z-score=-1.126, P=0.130; (TAAA)n: z-score=-0.233, 
      P=0.408; C1334T: z-score=0.703, P=0.241; C10991T: z-score=0.551, P=0.291] were 
      also not significant. Although our data are negative, the intriguing hypothesis 
      for MOG in SCZ may warrant further investigation of this gene.
FAU - Zai, G
AU  - Zai G
AD  - Neurogenetics Section, Centre for Addiction and Mental Health - Clarke Site, 
      Department of Psychiatry, University of Toronto, Canada.
FAU - King, N
AU  - King N
FAU - Wigg, K
AU  - Wigg K
FAU - Couto, J
AU  - Couto J
FAU - Wong, G W H
AU  - Wong GW
FAU - Honer, W G
AU  - Honer WG
FAU - Barr, C L
AU  - Barr CL
FAU - Kennedy, J L
AU  - Kennedy JL
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Frequency
MH  - *Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Matched-Pair Analysis
MH  - Middle Aged
MH  - Myelin Proteins
MH  - Myelin-Associated Glycoprotein/*genetics
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Nuclear Family
MH  - Oligodendroglia
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - Reference Values
MH  - Schizophrenia/*genetics
EDAT- 2005/01/22 09:00
MHDA- 2005/04/30 09:00
CRDT- 2005/01/22 09:00
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/04/30 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - GBB089 [pii]
AID - 10.1111/j.1601-183X.2004.00089.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2005 Feb;4(1):2-9. doi: 10.1111/j.1601-183X.2004.00089.x.