PMID- 15661373
OWN - NLM
STAT- MEDLINE
DCOM- 20050512
LR  - 20071114
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 133
IP  - 1
DP  - 2005 Jan 5
TI  - 3,4-Methylenedioxymethamphetamine increases neuropeptide messenger RNA expression 
      in rat striatum.
PG  - 131-42
AB  - The amphetamine analog 3,4-methylenedioxymethamphetamine (MDMA) is also known as 
      the recreational drug of abuse, Ecstasy. Several neuropeptides are found in 
      striatal neurons postsynaptic to dopamine and serotonin nerve terminals, and 
      changes in neuropeptide neurotransmission may be important for behavioral effects 
      of 3,4-methylenedioxymethamphetamine. This study used in situ hybridization to 
      characterize the effects of 3,4-methylenedioxymethamphetamine on four 
      neuropeptide mRNAs: preprodynorphin, preprotachykinin, neurotensin/neuromedin N, 
      and preproenkephalin. Male, Sprague-Dawley rats received a single administration 
      of 10 mg/kg 3,4-methylenedioxymethamphetamine and were sacrificed 30 min or 3 h 
      later. Three hours after administration, 3,4-methylenedioxymethamphetamine 
      increased preprodynorphin, preprotachykinin, and neurotensin/neuromedin N mRNAs. 
      These increases were most prominent in ventral and medial aspects of the 
      rostral-middle striatum, and then became more dorsally restricted in the caudal 
      striatum. At the 30-minute time point, MDMA significantly decreased the signal 
      for preproenkephalin mRNA in a general manner but did not affect the signal for 
      the other neuropeptide precursors. These data suggest that 
      3,4-methylenedioxymethamphetamine has a generalized, transient, inhibitory effect 
      on striatopallidal neuron gene expression, and then preferentially influences 
      striatonigral neuropeptide systems at the later time point in a regionally 
      selective manner.
FAU - Adams, David H
AU  - Adams DH
AD  - Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 
      East, Rm. 201, Salt Lake City, UT 84112-5820, USA.
FAU - Hanson, Glen R
AU  - Hanson GR
FAU - Keefe, Kristen A
AU  - Keefe KA
LA  - eng
GR  - DA09407/DA/NIDA NIH HHS/United States
GR  - DA13376/DA/NIDA NIH HHS/United States
GR  - K05 DA00378/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Neuropeptides)
RN  - 0 (RNA, Messenger)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*pharmacology
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Animals
MH  - Autoradiography/methods
MH  - Corpus Striatum/anatomy & histology/*drug effects/metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - In Situ Hybridization/methods
MH  - Male
MH  - Neuropeptides/genetics/*metabolism
MH  - Nucleus Accumbens/drug effects
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2005/01/22 09:00
MHDA- 2005/05/13 09:00
CRDT- 2005/01/22 09:00
PHST- 2004/10/01 00:00 [accepted]
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/05/13 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - S0169-328X(04)00472-3 [pii]
AID - 10.1016/j.molbrainres.2004.10.005 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2005 Jan 5;133(1):131-42. doi: 
      10.1016/j.molbrainres.2004.10.005.