PMID- 15661382
OWN - NLM
STAT- MEDLINE
DCOM- 20050920
LR  - 20200403
IS  - 0264-410X (Print)
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 23
IP  - 11
DP  - 2005 Feb 3
TI  - Immunisation with virion-loaded plasmacytoid or myeloid dendritic cells induces 
      primary Th-1 immune responses.
PG  - 1343-50
AB  - Dendritic cells (DCs) induce different types of immune responses depending on 
      their lineage and activation signals. When exposed to inactivated 
      pseudorabiesvirus (iPRV), plasmacytoid but not myeloid DCs released IFN-alpha and 
      IL-12. Remarkably, both iPRV-pulsed DC types were able to induce primary 
      IFN-gamma producing T cells and IgG isotype switching in vivo. In contrast, 
      tetanus toxoid pulsed DCs did not induce detectable primary immune responses. The 
      efficacy of antiviral T and B cell priming proved dependent on the recipient's 
      genotype. We conclude that either plasmacytoid or myeloid DCs pulsed with 
      inactivated virus suffice to induce primary Th1-polarised immune responses.
FAU - Wit, Marel C de
AU  - Wit MC
AD  - Virology Unit, Department of Infectious Diseases and Immunology, Veterinary 
      Faculty, Utrecht University, 3584 CL Utrecht, The Netherlands.
FAU - Horzinek, Marian C
AU  - Horzinek MC
FAU - Haagmans, Bart L
AU  - Haagmans BL
FAU - Schijns, Virgil E J C
AU  - Schijns VE
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukin-5)
RN  - 0 (Tetanus Toxoid)
RN  - 0 (Viral Vaccines)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Dendritic Cells/cytology/*immunology/*virology
MH  - Herpesvirus 1, Suid/*immunology
MH  - Immunoglobulin G/analysis
MH  - Interferon-alpha/biosynthesis
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/biosynthesis
MH  - Interleukin-5
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myeloid Cells/immunology
MH  - Plasma Cells/immunology
MH  - Tetanus Toxoid/immunology
MH  - Th1 Cells/*immunology
MH  - Viral Vaccines/*immunology
MH  - Virion/immunology
PMC - PMC7115573
EDAT- 2005/01/22 09:00
MHDA- 2005/09/21 09:00
PMCR- 2004/10/31
CRDT- 2005/01/22 09:00
PHST- 2004/03/09 00:00 [received]
PHST- 2004/09/20 00:00 [accepted]
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/09/21 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
PHST- 2004/10/31 00:00 [pmc-release]
AID - S0264-410X(04)00692-9 [pii]
AID - 10.1016/j.vaccine.2004.09.014 [doi]
PST - ppublish
SO  - Vaccine. 2005 Feb 3;23(11):1343-50. doi: 10.1016/j.vaccine.2004.09.014.