PMID- 15661648
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20191210
IS  - 1567-133X (Print)
IS  - 1567-133X (Linking)
VI  - 5
IP  - 3
DP  - 2005 Feb
TI  - Distinct developmental expression of Drosophila retinoblastoma factors.
PG  - 411-21
AB  - Retinoblastoma (RB) tumor suppressor proteins are important regulators of the 
      cell cycle and are implicated in a wide variety of human tumors. Genetic analysis 
      of RB mutations in humans and in model systems indicates that individual RB 
      proteins also have distinct functions in development. Specific target genes or 
      mechanisms of action of individual RB proteins in developmental contexts are not 
      well understood, however. To better understand the developmental activities of 
      the two RB family members in Drosophila, we have characterized endogenous 
      expression patterns of Rbf1 and Rbf2 proteins and transcripts in embryos and 
      imaginal discs. These gene products are coexpressed at several stages of 
      development, however, spatial and temporal differences are evident, including 
      partly complementary patterns of expression in the embryonic central nervous 
      system.
FAU - Keller, Scott A
AU  - Keller SA
AD  - Department of Biochemistry and Molecular Biology, Michigan State University, East 
      Lansing, MI 48824-1319, USA.
FAU - Ullah, Zakir
AU  - Ullah Z
FAU - Buckley, Martin S
AU  - Buckley MS
FAU - Henry, R William
AU  - Henry RW
FAU - Arnosti, David N
AU  - Arnosti DN
LA  - eng
GR  - R01 GM59805/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene Expr Patterns
JT  - Gene expression patterns : GEP
JID - 101167473
RN  - 0 (Drosophila Proteins)
RN  - 0 (RBF2 protein, Drosophila)
RN  - 0 (Rbf protein, Drosophila)
RN  - 0 (Repressor Proteins)
RN  - 0 (Retinoblastoma Protein)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Drosophila Proteins/*biosynthesis/immunology
MH  - Drosophila melanogaster/embryology
MH  - Embryo, Nonmammalian/metabolism
MH  - Eye/embryology
MH  - Gene Expression
MH  - *Genes, Retinoblastoma
MH  - Immunohistochemistry
MH  - Repressor Proteins/*biosynthesis/immunology
MH  - Retinoblastoma Protein
MH  - Tissue Distribution
MH  - Transcription Factors/*biosynthesis/immunology
EDAT- 2005/01/22 09:00
MHDA- 2005/07/22 09:00
CRDT- 2005/01/22 09:00
PHST- 2003/10/22 00:00 [received]
PHST- 2004/09/07 00:00 [revised]
PHST- 2004/09/08 00:00 [accepted]
PHST- 2005/01/22 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2005/01/22 09:00 [entrez]
AID - S1567-133X(04)00142-5 [pii]
AID - 10.1016/j.modgep.2004.09.005 [doi]
PST - ppublish
SO  - Gene Expr Patterns. 2005 Feb;5(3):411-21. doi: 10.1016/j.modgep.2004.09.005.