PMID- 15663364
OWN - NLM
STAT- MEDLINE
DCOM- 20050628
LR  - 20191109
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 24
IP  - 5
DP  - 2004
TI  - The impact of extracellular acidosis on dendritic cell function.
PG  - 363-84
AB  - Dendritic cells (DCs) are the most efficient antigen-presenting cells. They are 
      activated in the periphery by conserved pathogen molecules and by inflammatory 
      mediators produced by a variety of cell types in response to danger signals. It 
      is widely appreciated that inflammatory responses in peripheral tissues are 
      usually associated with the development of acidic microenvironments. 
      Surprisingly, there are relatively few studies directed to analyze the effect of 
      extracellular acidosis on the immune response. We focus on the influence of 
      extracellular acidosis on the function of immature DCs. The results presented 
      here show that acidosis activates DCs. It increases the acquisition of 
      extracellular antigens for MHC class I-restricted presentation and the ability of 
      antigen-pulsed DCs to induce both specific CD8+ CTL and B-cell responses. These 
      findings may have important implications to our understanding of the mechanisms 
      through which DCs sense the presence of infection or inflammation in nonlymphoid 
      tissues.
FAU - Vermeulen, Monica Elba
AU  - Vermeulen ME
AD  - Institute of Hematologic Research, National Academy of Medicine, Department of 
      Microbiology, Buenos Aires University School of Medicine, Buenos Aires, 
      Argentina.
FAU - Gamberale, Romina
AU  - Gamberale R
FAU - Trevani, Analia Silvina
AU  - Trevani AS
FAU - Martinez, Diego
AU  - Martinez D
FAU - Ceballos, Ana
AU  - Ceballos A
FAU - Sabatte, Juan
AU  - Sabatte J
FAU - Giordano, Mirta
AU  - Giordano M
FAU - Geffner, Jorge Raul
AU  - Geffner JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
RN  - 0 (Antigens)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Antigen)
SB  - IM
MH  - Acidosis/*metabolism
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Antigens/immunology
MH  - Cell Movement/immunology
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Humans
MH  - Inflammation/metabolism
MH  - Lymphoid Tissue/cytology/immunology
MH  - Membrane Proteins/immunology
MH  - Neoplasms/metabolism
MH  - Pinocytosis/immunology
MH  - Receptors, Antigen/immunology
RF  - 232
EDAT- 2005/01/25 09:00
MHDA- 2005/06/29 09:00
CRDT- 2005/01/25 09:00
PHST- 2005/01/25 09:00 [pubmed]
PHST- 2005/06/29 09:00 [medline]
PHST- 2005/01/25 09:00 [entrez]
AID - 1e5f41565309d988,1ad549c5344f5112 [pii]
AID - 10.1615/critrevimmunol.v24.i5.40 [doi]
PST - ppublish
SO  - Crit Rev Immunol. 2004;24(5):363-84. doi: 10.1615/critrevimmunol.v24.i5.40.