PMID- 15663745
OWN - NLM
STAT- MEDLINE
DCOM- 20050602
LR  - 20220321
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 1
DP  - 2005 Jan
TI  - Association of interleukin-18 gene single-nucleotide polymorphisms with 
      susceptibility to inflammatory bowel disease.
PG  - 88-92
AB  - Interleukin-18 (IL-18) is believed to be one of the most important cytokines in 
      the pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to 
      clarify the significance of single-nucleotide polymorphisms (SNPs) at the 5'-end 
      of the IL-18 gene in the development of IBD. DNA was obtained from peripheral 
      blood of 99 patients with ulcerative colitis (UC), 79 patients with Crohn's 
      disease (CD), and 102 healthy controls. All participants were Japanese. SNPs at 
      -656G/T, -607C/A, -137G/C, +113T/G, and +127C/T were determined by means of 
      direct sequencing, and a genetic association with IBD was examined. The 
      frequencies of the G allele at +113 and the T allele at +127 were significantly 
      higher in patients with CD and UC compared with controls. The differences in 
      allelic frequencies were more striking in patients with CD than in patients with 
      UC, and at position +127 than at position +113. The haplotype estimation, 
      according to the E-M algorithm, suggested that TACGT is closely associated with 
      IBD, especially with CD. It was concluded that SNPs at the 5'-end of IL-18 gene 
      might be closely related to the etiology of IBD.
FAU - Aizawa, Y
AU  - Aizawa Y
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      Jikei University School of Medicine, Tokyo, Japan. y-aizawa@qa2.so-net.ne.jp
FAU - Sutoh, S
AU  - Sutoh S
FAU - Matsuoka, M
AU  - Matsuoka M
FAU - Negishi, M
AU  - Negishi M
FAU - Torii, A
AU  - Torii A
FAU - Miyakawa, Y
AU  - Miyakawa Y
FAU - Sugisaka, H
AU  - Sugisaka H
FAU - Nakamura, M
AU  - Nakamura M
FAU - Toda, G
AU  - Toda G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Interleukin-18)
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Inflammatory Bowel Diseases/*genetics
MH  - Interleukin-18/*genetics
MH  - Likelihood Functions
MH  - Polymorphism, Single Nucleotide
EDAT- 2005/01/25 09:00
MHDA- 2005/06/03 09:00
CRDT- 2005/01/25 09:00
PHST- 2005/01/25 09:00 [pubmed]
PHST- 2005/06/03 09:00 [medline]
PHST- 2005/01/25 09:00 [entrez]
AID - TAN336 [pii]
AID - 10.1111/j.1399-0039.2005.00336.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Jan;65(1):88-92. doi: 10.1111/j.1399-0039.2005.00336.x.