PMID- 15663750
OWN - NLM
STAT- MEDLINE
DCOM- 20050602
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 1
DP  - 2005 Jan
TI  - Extended DR3-D6S273-HLA-B haplotypes are associated with increased susceptibility 
      to type 1 diabetes in US Caucasians.
PG  - 115-9
AB  - Human leukocyte antigen (HLA)-DR3 haplotypes are associated with susceptibility 
      to type 1 diabetes (T1D). Reports from Northern European populations show that an 
      allele (D6S273*2) at a microsatellite mapping to HLA class III marks an extended 
      DR3-B18 haplotype associated with increased susceptibility to T1D. Consistent 
      with previous reports, D6S273*2 marked a highly predisposing DR3 haplotype in 
      European origin, multiplex families from the USA. Furthermore, we observed on DR3 
      haplotypes that other D6S273 alleles were also significantly associated with both 
      increased transmission (D6S273*5; P < 0.02) and decreased transmission (D6S273*7; 
      P < 0.05) to affected individuals. The differential transmission was most evident 
      among DR3-B8 haplotypes. Neither HLA-B*1801 nor any alleles of D6S273 were 
      associated with increased T1D predisposition on DR4 haplotypes. These data 
      indicate that multiple alleles of D6S273 mark a susceptibility locus whose effect 
      we were able to detect only among DR3 haplotypes but not limited to DR3-B18 
      haplotypes.
FAU - Valdes, A M
AU  - Valdes AM
AD  - Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
FAU - Wapelhorst, B
AU  - Wapelhorst B
FAU - Concannon, P
AU  - Concannon P
FAU - Erlich, H A
AU  - Erlich HA
FAU - Thomson, G
AU  - Thomson G
FAU - Noble, J A
AU  - Noble JA
LA  - eng
GR  - DK46635/DK/NIDDK NIH HHS/United States
GR  - DK61722/DK/NIDDK NIH HHS/United States
GR  - DK46626/DK/NIDDK NIH HHS/United States
GR  - R01 DK061722/DK/NIDDK NIH HHS/United States
GR  - U24 AI-49213/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-DR3 Antigen/*genetics/immunology
MH  - HLA-DR4 Antigen/genetics/immunology
MH  - *Haplotypes
MH  - Humans
MH  - United States
MH  - White People
EDAT- 2005/01/25 09:00
MHDA- 2005/06/03 09:00
CRDT- 2005/01/25 09:00
PHST- 2005/01/25 09:00 [pubmed]
PHST- 2005/06/03 09:00 [medline]
PHST- 2005/01/25 09:00 [entrez]
AID - TAN348 [pii]
AID - 10.1111/j.1399-0039.2005.00348.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Jan;65(1):115-9. doi: 10.1111/j.1399-0039.2005.00348.x.