PMID- 15664938
OWN - NLM
STAT- MEDLINE
DCOM- 20050311
LR  - 20181113
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 73
IP  - 2
DP  - 2005 Feb
TI  - Protective levels of polysaccharide-specific maternal antibodies may enhance the 
      immune response elicited by pneumococcal conjugates in neonatal and infant mice.
PG  - 956-64
AB  - Maternal antibodies (MatAbs) may protect the offspring against infections but may 
      also interfere with their immune responses to vaccination. We have previously 
      shown that maternal immunization with pneumococcal polysaccharides (PPS) 
      conjugated to tetanus protein (Pnc-TT) protected the offspring against infections 
      caused by three important pediatric serotypes. To study the influence of MatAb on 
      the immune response to Pnc-TT early in life, adult female mice were immunized 
      twice with Pnc-TT of serotype 1 (Pnc1-TT), and their offspring received Pnc1-TT 
      subcutaneously three times at 3-week intervals starting at 1 week (neonatal) or 3 
      weeks (infant) of age. High levels of PPS-1-specific MatAb (>3 log) in offspring 
      of Pnc1-TT-immunized dams completely inhibited their anti-PPS-1 response elicited 
      by Pnc1-TT. In contrast, low or moderate ( approximately 1 to 2 log) levels of 
      MatAb did not interfere with and even enhanced the immune response of the 
      offspring, and a booster response to a second Pnc1-TT dose was observed. 
      Carrier-specific MatAbs had little effect on the response of offspring to the 
      conjugate. All Pnc1-TT-immunized offspring were protected against pneumococcal 
      bacteremia and had reduced lung infection. These results demonstrate that in the 
      presence of MatAb, Pnc1-TT may elicit a protective PPS-1-specific antibody 
      response and prime for PPS-1-specific memory in young offspring. Importantly, low 
      or moderate levels of PPS-1-specific MatAb not only provided protection against 
      pneumococcal infections but also enhanced the immune response elicited by Pnc1-TT 
      in neonatal and infant mice. This murine model will be used to develop novel 
      strategies combining maternal and neonatal immunization to protect against 
      infections caused by encapsulated bacteria in early life.
FAU - Richter, Margret Y
AU  - Richter MY
AD  - Department of Immunology, Landspitali-University Hospital, Hringbraut, 101 
      Reykjavik, Iceland.
FAU - Jakobsen, Havard
AU  - Jakobsen H
FAU - Haeuw, Jean-Francois
AU  - Haeuw JF
FAU - Power, Ultan F
AU  - Power UF
FAU - Jonsdottir, Ingileif
AU  - Jonsdottir I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antibodies)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 0 (pneumococcal polysaccharide type 1)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antibodies/*immunology
MH  - Bacteremia/immunology
MH  - Mice
MH  - Pneumonia/immunology
MH  - Polysaccharides, Bacterial/*immunology
MH  - Streptococcus pneumoniae/*immunology
PMC - PMC546934
EDAT- 2005/01/25 09:00
MHDA- 2005/03/12 09:00
PMCR- 2005/02/01
CRDT- 2005/01/25 09:00
PHST- 2005/01/25 09:00 [pubmed]
PHST- 2005/03/12 09:00 [medline]
PHST- 2005/01/25 09:00 [entrez]
PHST- 2005/02/01 00:00 [pmc-release]
AID - 73/2/956 [pii]
AID - 0546-04 [pii]
AID - 10.1128/IAI.73.2.956-964.2005 [doi]
PST - ppublish
SO  - Infect Immun. 2005 Feb;73(2):956-64. doi: 10.1128/IAI.73.2.956-964.2005.