PMID- 15665388
OWN - NLM
STAT- MEDLINE
DCOM- 20050505
LR  - 20190608
IS  - 0278-0240 (Print)
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 20
IP  - 6
DP  - 2004
TI  - The matrix metalloproteinase-3 (MMP-3) 5A/6A promoter polymorphism is not 
      associated with ischaemic heart disease: analysis employing a family based 
      approach.
PG  - 289-94
AB  - Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of 
      the atherosclerotic process. The possible role of the functional -1612 5A/6A 
      polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease 
      (IHD) was investigated in a well-defined Irish population using two recently 
      described family based tests of association. One thousand and twelve individuals 
      from 386 families with at least one member prematurely affected with IHD were 
      genotyped. Using the combined transmission disequilibrium test (TDT)/sib-TDT and 
      the pedigree disequilibrium test (PDT), no association between the MMP-3 -1612 
      5A/6A polymorphism and IHD was found. Our data demonstrate that, in an Irish 
      population, the MMP-3 -1612 5A/6A polymorphism is not associated with IHD.
FAU - McGlinchey, Paul G
AU  - McGlinchey PG
AD  - Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, 
      Belfast, BT12 6BA, UK.
FAU - Spence, Mark S
AU  - Spence MS
FAU - Patterson, Chris C
AU  - Patterson CC
FAU - Allen, Adrian R
AU  - Allen AR
FAU - Murphy, Gillian
AU  - Murphy G
FAU - Fogarty, Damian
AU  - Fogarty D
FAU - Evans, Alun
AU  - Evans A
FAU - McKeown, Pascal P
AU  - McKeown PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Family Health
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Heart Diseases/*genetics
MH  - Humans
MH  - Ireland
MH  - Linkage Disequilibrium
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Myocardial Ischemia/*genetics
MH  - Pedigree
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - *Promoter Regions, Genetic
MH  - Risk Factors
MH  - Sequence Analysis, DNA
PMC - PMC3839324
EDAT- 2005/01/25 09:00
MHDA- 2005/05/06 09:00
PMCR- 2005/01/18
CRDT- 2005/01/25 09:00
PHST- 2005/01/25 09:00 [pubmed]
PHST- 2005/05/06 09:00 [medline]
PHST- 2005/01/25 09:00 [entrez]
PHST- 2005/01/18 00:00 [pmc-release]
AID - 10.1155/2004/715745 [doi]
PST - ppublish
SO  - Dis Markers. 2004;20(6):289-94. doi: 10.1155/2004/715745.