PMID- 15667840
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20161124
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 58
IP  - 9
DP  - 2005 Mar
TI  - Biomonitoring of persistent organochlorine pesticides, PCDD/PCDFs and dioxin-like 
      PCBs in blood of children from South West Germany (Baden-Wuerttemberg) from 1993 
      to 2003.
PG  - 1185-201
AB  - In the context of a monitoring program, persistent organic pollutants (POPs) were 
      quantified in the blood of 10 year old children at four different demographic 
      regions in Baden-Wuerttemberg, a highly industrialised federal state in South 
      West Germany. DDE, HCB, PCB 138, PCB 153 and PCB 180 were measured in 1996/1997, 
      1998/1999, 2000/2001 and 2002/2003 in individual samples of about 400 children 
      per year. PCDD/PCDFs and some relevant coplanar PCBs were determined in pooled 
      samples from children in seven cycles from 1993 to 2003. Blood concentrations of 
      the investigated compounds decreased in that time period by a factor of 2-4 with 
      the exception of most PCDFs. The concentrations of POPs in the blood of the 
      children were distinctly lower than the concentrations reported for adults. 
      Breast feeding was associated with about 30% higher median concentrations of DDE, 
      HCB, PCBs and a 30% increase for mean PCDD/PCDF concentrations. Concerning 
      demographic differences, significant lower concentrations of HCB, PCBs and 
      PCDD/PCDFs could be seen in children from Mannheim compared to the region of 
      Aulendorf. About 10-20% higher concentrations were found in boys compared to 
      girls for HCB, indicator PCBs and PCDD/PCDFs. The pattern of non-ortho and 
      mono-ortho PCBs in the blood of children was similar to the pattern reported for 
      mother's milk, and PCB 126 and PCB 156 contributed about 70% to the toxicity of 
      dioxin-like PCBs and about one-third to total TEQ including PCDD/PCDFs.
FAU - Link, Bernhard
AU  - Link B
AD  - Baden-Wuerttemberg State Health Office (Landesgesundheitsamt), Wiederholdstr. 15, 
      70174 Stuttgart, Germany. link@lga.bwl.de
FAU - Gabrio, Thomas
AU  - Gabrio T
FAU - Zoellner, Iris
AU  - Zoellner I
FAU - Piechotowski, Isolde
AU  - Piechotowski I
FAU - Paepke, Olaf
AU  - Paepke O
FAU - Herrmann, Thomas
AU  - Herrmann T
FAU - Felder-Kennel, Andrea
AU  - Felder-Kennel A
FAU - Maisner, Valentina
AU  - Maisner V
FAU - Schick, Karl-Heinz
AU  - Schick KH
FAU - Schrimpf, Monika
AU  - Schrimpf M
FAU - Schwenk, Michael
AU  - Schwenk M
FAU - Wuthe, Juergen
AU  - Wuthe J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Lipids)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Benzofurans/*blood
MH  - Breast Feeding
MH  - Child
MH  - Dibenzofurans, Polychlorinated
MH  - Dichlorodiphenyl Dichloroethylene/*blood
MH  - Dioxins/*blood
MH  - Environmental Monitoring/statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fungicides, Industrial/*blood
MH  - Germany, West
MH  - Hexachlorobenzene/*blood
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Polychlorinated Biphenyls/*blood
MH  - Sex Factors
MH  - Time Factors
EDAT- 2005/01/26 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/01/26 09:00
PHST- 2004/03/08 00:00 [received]
PHST- 2004/09/16 00:00 [revised]
PHST- 2004/09/30 00:00 [accepted]
PHST- 2005/01/26 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/01/26 09:00 [entrez]
AID - S0045-6535(04)00858-6 [pii]
AID - 10.1016/j.chemosphere.2004.09.061 [doi]
PST - ppublish
SO  - Chemosphere. 2005 Mar;58(9):1185-201. doi: 10.1016/j.chemosphere.2004.09.061.