PMID- 15668828
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20181113
IS  - 0300-5860 (Print)
IS  - 0300-5860 (Linking)
VI  - 94
IP  - 1
DP  - 2005 Jan
TI  - Coronary artery spasm induced by 5-fluorouracil.
PG  - 33-7
AB  - The frequently used chemotherapeutic drug 5-fluorouracil (5-FU) is known to cause 
      angina pectoris and arrhythmias; myocardial infarction and sudden cardiac death 
      could occur. Potential reasons for these phenomena range from toxic/metabolic 
      disturbances to coronary artery spasms. This report shows angiographically proven 
      spasmophilia of the coronary arteries and contributes to the understanding of 
      angina pectoris occurring during treatment with 5-FU. Thus, verapamil type 
      calcium antagonists as well as nitrates should be administered primarily in 
      patients with coronary artery disease and in all patients who had been 
      symptomatic during 5-FU administration in order to prevent further episodes.
FAU - Alter, P
AU  - Alter P
AD  - Philipps University of Marburg/Lahn, Department of Internal Medicine-Cardiology, 
      Baldingerstrasse, 35033 Marburg, Germany. palter@med.uni-marburg.de
FAU - Herzum, M
AU  - Herzum M
FAU - Schaefer, J R
AU  - Schaefer JR
FAU - Maisch, B
AU  - Maisch B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Z Kardiol
JT  - Zeitschrift fur Kardiologie
JID - 0360430
RN  - Q20Q21Q62J (Cisplatin)
RN  - Q573I9DVLP (Leucovorin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adenocarcinoma/*drug therapy/surgery
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use/*toxicity
MH  - Cisplatin/administration & dosage/toxicity
MH  - Coronary Angiography
MH  - Coronary Circulation/drug effects
MH  - Coronary Vasospasm/*chemically induced/diagnostic imaging
MH  - Electrocardiography/drug effects
MH  - Esophageal Neoplasms/*drug therapy/surgery
MH  - Esophagectomy
MH  - Exercise Test/drug effects
MH  - Fluorouracil/administration & dosage/*toxicity
MH  - Humans
MH  - Leucovorin/administration & dosage/toxicity
MH  - Male
MH  - Neoadjuvant Therapy/*adverse effects
MH  - Regional Blood Flow/drug effects
EDAT- 2005/01/26 09:00
MHDA- 2005/06/01 09:00
CRDT- 2005/01/26 09:00
PHST- 2004/03/26 00:00 [received]
PHST- 2004/08/12 00:00 [accepted]
PHST- 2005/01/26 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2005/01/26 09:00 [entrez]
AID - 10.1007/s00392-005-0159-8 [doi]
PST - ppublish
SO  - Z Kardiol. 2005 Jan;94(1):33-7. doi: 10.1007/s00392-005-0159-8.