PMID- 15671100
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20220311
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 90
IP  - 4
DP  - 2005 Apr
TI  - Urinary markers of adrenarche: reference values in healthy subjects, aged 3-18 
      years.
PG  - 2015-21
AB  - Information on the urinary excretion of dehydroepiandrosterone (DHEA) and its 
      direct metabolites is scarce for healthy subjects during growth. We used gas 
      chromatography-mass spectrometry urinary steroid profiling to noninvasively study 
      adrenarchal metabolome in 400 healthy subjects, aged 3-18 yr. Urinary 24-h 
      excretion rates of DHEA did not increase significantly before age 7-8 yr. 
      However, DHEA together with its 16alpha-hydroxylated downstream metabolites, 
      16alpha-hydroxy-DHEA and 3beta,16alpha,17beta-androstenetriol (DHEA&M), as well 
      as the DHEA metabolite, 5-androstene-3beta,17beta-diol (ADIOL), and the sum of 
      major urinary androgen metabolites (C19) rose consistently from the youngest to 
      the oldest age group. The significant increases (P < 0.01) observed for 24-h 
      excretion rates of C19, ADIOL, and DHEA&M were 2- to 4-fold in boys and girls 
      between age 3 and 8 yr. DHEA&M, for example, rose from about 20 to 80 microg/d (P 
      < 0.0001) during this period. Until the age of 16 yr, DHEA&M excretion also 
      increased to nearly 1000 microg/d. Patterns of steroidogenic enzyme activities 
      were assessed (from definite ratios of urinary steroid metabolites) for 
      21-hydroxylase, 3beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid 
      dehydrogenase, and 5alpha-reductase. Our results indicate for healthy boys and 
      girls that adrenarche is a gradual process starting much earlier than hitherto 
      believed. Efficient metabolism of DHEA, especially to 16-hydroxylated steroids, 
      may explain the almost constant levels seen for this steroid until age 7-8 yr. 
      The established reference values for DHEA, DHEA&M, ADIOL, C19 (including 
      androsterone and etiocholanolone), and urinary parameters of steroidogenic enzyme 
      activities could be useful to identify nutritional, environmental, and 
      pathophysiological interrelations with the progressive maturational process of 
      adrenarche. Our data may also be used as reference data for the diagnosis of 
      steroid-related disorders.
FAU - Remer, Thomas
AU  - Remer T
AD  - Department of Nutrition and Health, Research Institute of Child Nutrition, 
      Heinstuck 11, 44225 Dortmund, Germany. remer@fke-do.de
FAU - Boye, Kai R
AU  - Boye KR
FAU - Hartmann, Michaela F
AU  - Hartmann MF
FAU - Wudy, Stefan A
AU  - Wudy SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050125
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Biomarkers)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - EC 1.1.- (3-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 3-Hydroxysteroid Dehydrogenases/urine
MH  - Adolescent
MH  - Age Factors
MH  - Biomarkers
MH  - Child
MH  - Child Development/*physiology
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Dehydroepiandrosterone/*urine
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Reference Values
MH  - Sex Factors
EDAT- 2005/01/27 09:00
MHDA- 2005/06/01 09:00
CRDT- 2005/01/27 09:00
PHST- 2005/01/27 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2005/01/27 09:00 [entrez]
AID - jc.2004-1571 [pii]
AID - 10.1210/jc.2004-1571 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2005 Apr;90(4):2015-21. doi: 10.1210/jc.2004-1571. Epub 
      2005 Jan 25.