PMID- 15671101
OWN - NLM
STAT- MEDLINE
DCOM- 20050531
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 90
IP  - 4
DP  - 2005 Apr
TI  - A polymorphism exon 1 variant at the locus of the scavenger receptor class B type 
      I (SCARB1) gene is associated with differences in insulin sensitivity in healthy 
      people during the consumption of an olive oil-rich diet.
PG  - 2297-300
AB  - Scavenger receptor class B type I (SCARB1) was described as the first 
      high-density lipoprotein receptor. Increasing evidence indicates that SCARB1 
      plays additional roles particularly in type 2 diabetes mellitus. Our aim was to 
      determine whether the presence of an exon 1 (G-->A) polymorphism at the SCARB1 
      gene modifies the insulin sensitivity to dietary fat. METHODS: We studied 59 
      healthy volunteers (30 men and 29 women, 42 G/G homozygous and 17 G/A 
      heterozygous). Subjects consumed three diets for 4 wk each: a saturated fatty 
      acid (SFA)-rich diet (38% fat, 20% SFA), followed by a carbohydrate (CHO)-rich 
      diet (30% fat, 55% CHO) or a monounsaturated fatty acid (MUFA)-rich diet (38% 
      fat, 22% MUFA) after a randomized crossover design. For each diet, we 
      investigated peripheral insulin sensitivity with the insulin suppression test. 
      RESULTS: Steady-state plasma glucose after the MUFA diet was lower in G/A 
      compared with G/G subjects (P = 0.030). This effect was not observed after CHO 
      and SFA diets (P = 0.177 and 0.957, respectively). Plasma nonesterified free 
      fatty acid values were lower in subjects carrying the A allele for all the diet 
      periods. CONCLUSIONS: Our findings show that carriers of the G/A genotype have 
      significant increases in insulin sensitivity after a MUFA-rich diet compared with 
      G/G individuals.
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
AD  - Units of Lipids and Artherosclerosis, Hospital Universitario Reina Sofia, Avenida 
      Menendez Pidal, sin numero 14004 Cordoba, Spain.
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
FAU - Bellido, Cecilia
AU  - Bellido C
FAU - Ordovas, Jose Maria
AU  - Ordovas JM
FAU - Moreno, Juan Antonio
AU  - Moreno JA
FAU - Marin, Carmen
AU  - Marin C
FAU - Gomez, Purificacion
AU  - Gomez P
FAU - Delgado-Lista, Javier
AU  - Delgado-Lista J
FAU - Fuentes, Francisco
AU  - Fuentes F
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
LA  - eng
GR  - HL54776/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050125
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Olive Oil)
RN  - 0 (Plant Oils)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (SCARB1 protein, human)
RN  - 0 (Scavenger Receptors, Class B)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/administration & dosage
MH  - Exons
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Olive Oil
MH  - Plant Oils/*administration & dosage
MH  - *Polymorphism, Genetic
MH  - Receptors, Immunologic/*genetics/physiology
MH  - Receptors, Scavenger
MH  - Scavenger Receptors, Class B
EDAT- 2005/01/27 09:00
MHDA- 2005/06/01 09:00
CRDT- 2005/01/27 09:00
PHST- 2005/01/27 09:00 [pubmed]
PHST- 2005/06/01 09:00 [medline]
PHST- 2005/01/27 09:00 [entrez]
AID - jc.2004-1489 [pii]
AID - 10.1210/jc.2004-1489 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2005 Apr;90(4):2297-300. doi: 10.1210/jc.2004-1489. Epub 
      2005 Jan 25.