PMID- 15672039
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20161124
IS  - 0002-9378 (Print)
IS  - 0002-9378 (Linking)
VI  - 192
IP  - 1
DP  - 2005 Jan
TI  - Effects of blockade of the endothelin receptor A and inhibition of nitric oxide 
      synthesis on uteroplacental and renal blood flow in awake pregnant rats.
PG  - 295-301
AB  - OBJECTIVE: The aim of this study was to evaluate the role of the ETA receptor and 
      nitric oxide (NO) in the regulation of uteroplacental and renal blood flow in 
      pregnant rats. STUDY DESIGN: Regional blood flows were measured by the 
      microsphere technique in pregnant Sprague-Dawley rats (term 23 days). Blood flow 
      was measured before and after ETA receptor blockade (BQ-123, 1 mg/kg) at 
      gestational day (GD) 19 or 21 (n=8 and n=9, respectively). In 2 additional groups 
      blood flow was measured before and after NO synthase inhibition (L-NAME 2 
      microg/min) at GD 19 or 21 (n=10 in each group). RESULTS: BQ-123 significantly 
      increased placental and myometrial blood flows by almost 80% and 35%, 
      respectively, at both gestational ages. BQ-123 did not alter renal blood flow. No 
      effect on placental or myometrial blood flow was observed after L-NAME infusion, 
      neither at GD 19 nor GD 21. Renal blood flow decreased by nearly 35% in both 
      groups after L-NAME. CONCLUSION: There is an important role for endogenous ET in 
      the regulation of uteroplacental blood flow in the rat. NO contributes to a 
      significant vasodilatation in the renal vasculature; however, NO appears not to 
      be involved in the maintenance of uteroplacental blood flow in the awake pregnant 
      rat.
FAU - Ajne, Gunilla
AU  - Ajne G
AD  - Department of Obstetrics and Gynecology, Karolinska University Hospital Huddinge, 
      Karolinska Institute, Stockholm, Sweden. gunilla.ajne@kus.se
FAU - Nisell, Henry
AU  - Nisell H
FAU - Jansson, Thomas
AU  - Jansson T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Endothelin Receptor Antagonists)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Peptides, Cyclic)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - S2A8YZM151 (cyclo(Trp-Asp-Pro-Val-Leu))
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Antihypertensive Agents/pharmacology
MH  - *Endothelin Receptor Antagonists
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Kidney/blood supply/*drug effects
MH  - NG-Nitroarginine Methyl Ester/*pharmacology
MH  - Nitric Oxide Synthase/*antagonists & inhibitors
MH  - Peptides, Cyclic/*pharmacology
MH  - Placenta/blood supply/*drug effects
MH  - Pregnancy
MH  - Pulsatile Flow
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Regional Blood Flow
EDAT- 2005/01/27 09:00
MHDA- 2005/03/04 09:00
CRDT- 2005/01/27 09:00
PHST- 2005/01/27 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2005/01/27 09:00 [entrez]
AID - S0002937804004545 [pii]
AID - 10.1016/j.ajog.2004.04.035 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2005 Jan;192(1):295-301. doi: 10.1016/j.ajog.2004.04.035.