PMID- 15672412
OWN - NLM
STAT- MEDLINE
DCOM- 20060725
LR  - 20141120
IS  - 0263-6484 (Print)
IS  - 0263-6484 (Linking)
VI  - 24
IP  - 3
DP  - 2006 May-Jun
TI  - Macromolecular oxidation in anisotonic suspensions of mouse spleen cells.
PG  - 201-7
AB  - Macromolecular oxidative alterations have been analysed in vitro in anisotonic 
      suspensions of mouse splenocytes. Both hypertonicity and hypotonicity induced the 
      generation of thiobarbituric acid reactive species (TBARS) and carbonylation of 
      the proteins, which took place along with cell death. Addition of antioxidants 
      partially inhibited oxidative changes in isotonic and hypotonic suspensions. 
      Anisotonic shock of mouse splenocytes proved to be an inducer of oxidative 
      stress. The oxidative macromolecular alterations might contribute to pathogenesis 
      of cell death caused by osmotic stress.
CI  - Copyright (c) 2005 John Wiley & Sons, Ltd.
FAU - Bilic, Ivan
AU  - Bilic I
AD  - Department of Pathophysiology, Medical School, University of Zagreb, Zagreb, 
      Croatia. ibilic@mef.hr
FAU - Kovac, Zdenko
AU  - Kovac Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Hypertonic Solutions)
RN  - 0 (Hypotonic Solutions)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
SB  - IM
MH  - Animals
MH  - Cell Death/drug effects
MH  - Hypertonic Solutions/*pharmacology
MH  - Hypotonic Solutions/*pharmacology
MH  - In Vitro Techniques
MH  - Macromolecular Substances/analysis
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Osmotic Pressure/drug effects
MH  - Oxidation-Reduction/drug effects
MH  - Oxidative Stress/drug effects
MH  - Protein Carbonylation/drug effects/physiology
MH  - Spleen/cytology/*drug effects/*metabolism
MH  - Thiobarbituric Acid Reactive Substances/*analysis
EDAT- 2005/01/27 09:00
MHDA- 2006/07/26 09:00
CRDT- 2005/01/27 09:00
PHST- 2005/01/27 09:00 [pubmed]
PHST- 2006/07/26 09:00 [medline]
PHST- 2005/01/27 09:00 [entrez]
AID - 10.1002/cbf.1207 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2006 May-Jun;24(3):201-7. doi: 10.1002/cbf.1207.