PMID- 1567305
OWN - NLM
STAT- MEDLINE
DCOM- 19920519
LR  - 20061115
IS  - 0005-2086 (Print)
IS  - 0005-2086 (Linking)
VI  - 36
IP  - 1
DP  - 1992 Jan-Mar
TI  - Reaction of the avian respiratory system to intratracheally administered 
      avirulent Salmonella typhimurium.
PG  - 24-9
AB  - Chickens were inoculated intratracheally (IT) with the SR-11 Salmonella 
      typhimurium deletion mutant x4062 strain. Data collected for 8 days 
      postinoculation (PI) were: signs of respiratory and gastrointestinal disease; 
      histological lesions; the influx, phagocytic proportion, and phagocytic capacity 
      of avian respiratory phagocytes (ARPs); and the proportion of granulocytes vs. 
      macrophages in the lung tissues and lavage fluids of the lungs and air sacs. S. 
      typhimurium-inoculated chickens had no clinical signs of gastrointestinal or 
      respiratory disease but had various degrees of inflammatory changes in the lungs. 
      At 5 hr PI, S. typhimurium-inoculated chickens had approximately 53-fold more 
      ARPs than mock-inoculated controls. Between 26 hr and 8 days PI, the number of 
      ARPs from S. typhimurium-inoculated birds was not significantly higher than the 
      number from the mock-inoculated controls. Flow cytometric analysis of ARPs 
      demonstrated that the proportion of phagocytic ARPs and the phagocytic capacity 
      of ARPs from S. typhimurium-inoculated chickens were significantly higher between 
      5 and 26 hr PI than those of the ARPs from mock-inoculated chickens. Kinetic 
      changes over 8 days in the granulocyte/macrophage ratios in the lavage fluids, as 
      compared with kinetic changes in the lung tissues, suggested that the 
      granulocytes generally represent a much higher proportion of the ARPs, and egress 
      earlier and in much larger numbers from the tissues to the lumen of lungs and air 
      sacs than do macrophages.
FAU - Toth, T E
AU  - Toth TE
AD  - College of Veterinary Medicine, Virginia Polytechnic Institute and State 
      University, Blacksburg 24061.
FAU - Curtiss, R 3rd
AU  - Curtiss R 3rd
FAU - Veit, H
AU  - Veit H
FAU - Pyle, R H
AU  - Pyle RH
FAU - Siegel, P B
AU  - Siegel PB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Avian Dis
JT  - Avian diseases
JID - 0370617
SB  - IM
MH  - Animals
MH  - Cell Count/veterinary
MH  - *Chickens
MH  - Female
MH  - Lung/pathology
MH  - Phagocytes/cytology/immunology
MH  - Phagocytosis
MH  - Poultry Diseases/*immunology/microbiology
MH  - Respiratory System/*immunology/microbiology
MH  - Salmonella Infections, Animal/*immunology/microbiology
MH  - Salmonella typhimurium/*immunology/pathogenicity
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Avian Dis. 1992 Jan-Mar;36(1):24-9.