PMID- 15675476
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20191109
IS  - 1120-009X (Print)
IS  - 1120-009X (Linking)
VI  - 16 Suppl 5
DP  - 2004 Nov
TI  - Thoracic stop-flow perfusion in the treatment of refractory non small cell lung 
      cancer.
PG  - 40-3
AB  - This study was undertaken to determine the survival of patients with unresectable 
      and refractory non small cell lung cancer (NSCLC) submitted to thoracic stop-flow 
      perfusion (TSP). Forty-five patients with NSCLC confined to thoracic region 
      entered the study. All 45 patients had been pretreated with some form of 
      chemotherapy and had progression of disease. The cytostatic regimen was mitomycin 
      10 mg/m2, navelbine 25 mg/m2 and cisplatin 60 mg/m2. In 39/45 patients, 
      immediately after TSP, hemofiltration was performed to reduce systemic side 
      effects There were 16/45 responses to the first TSP (CR 0; PR 16): a response 
      rate of 35.6%. Median time to progression was 4 months. Median survival was 7.5 
      months.1-year survival rate was 36.4%, 2-year survival rate was 14%, and 3-year 
      survival rate was 5.7%.
FAU - Guadagni, S
AU  - Guadagni S
AD  - Dept of Surgical Sciences, University of L'Aquila, L'Aquila, Italy. 
      stefanoguadagni@interfree.it
FAU - Muller, H
AU  - Muller H
FAU - Valenti, M
AU  - Valenti M
FAU - Clementi, M
AU  - Clementi M
FAU - Fiorentini, G
AU  - Fiorentini G
FAU - Cantore, M
AU  - Cantore M
FAU - Amicucci, G
AU  - Amicucci G
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Chemother
JT  - Journal of chemotherapy (Florence, Italy)
JID - 8907348
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse 
      effects
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/mortality
MH  - Chemotherapy, Cancer, Regional Perfusion/*methods
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/mortality
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Thorax
EDAT- 2005/01/29 09:00
MHDA- 2005/02/11 09:00
CRDT- 2005/01/29 09:00
PHST- 2005/01/29 09:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2005/01/29 09:00 [entrez]
AID - 10.1080/1120009x.2004.11782382 [doi]
PST - ppublish
SO  - J Chemother. 2004 Nov;16 Suppl 5:40-3. doi: 10.1080/1120009x.2004.11782382.