PMID- 15676105
OWN - NLM
STAT- MEDLINE
DCOM- 20050524
LR  - 20191109
IS  - 1528-4042 (Print)
IS  - 1528-4042 (Linking)
VI  - 5
IP  - 1
DP  - 2005 Feb
TI  - New era for management of primary hypertensive intracerebral hemorrhage.
PG  - 29-35
AB  - This discussion focuses on recent reports relevant to improved understanding and 
      future directions in the management of intracerebral hemorrhage (ICH). Prevention 
      is possible with adequate treatment of hypertension; microbleeds, apolipoprotein 
      genotype, and cholesterol treatment have been examined in relation to ICH risk. 
      Hematoma products, matrix metalloproteinases, inflammatory markers, and means to 
      attenuate injury have also received attention. The multifaceted character of 
      perihematomal edema has been further defined but evidence for perihematomal 
      ischemia remains elusive. New data on acute blood pressure reinforces the need 
      for a clinical trial. With the lack of efficacy found in the International 
      Surgical Trial in Intracerebral Hemorrhage (ISTICH), a landmark surgical trial, 
      emphasis is shifting to minimally invasive and catheter/thrombolytic-based 
      technologies for clot evacuation. On the medical side, activated factor VII has 
      been shown to control hemorrhage growth. Looking forward, stem cell therapies for 
      ICH are under investigation and some outcome studies are shedding new rays of 
      hope.
FAU - Hall, Christiana E
AU  - Hall CE
AD  - Department of Neurology, University of Texas Houston Medical School, 6431 Fannin 
      Street, Houston, TX 77030, USA. chall@mcg.edu
FAU - Grotta, James C
AU  - Grotta JC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/pharmacology/therapeutic use
MH  - Blood Pressure/drug effects/physiology
MH  - Cerebrovascular Circulation/drug effects/physiology
MH  - Disease Management
MH  - Humans
MH  - Intracranial Hemorrhage, Hypertensive/*diagnosis/physiopathology/*therapy
MH  - Risk Factors
RF  - 45
EDAT- 2005/01/29 09:00
MHDA- 2005/05/25 09:00
CRDT- 2005/01/29 09:00
PHST- 2005/01/29 09:00 [pubmed]
PHST- 2005/05/25 09:00 [medline]
PHST- 2005/01/29 09:00 [entrez]
AID - 10.1007/s11910-005-0020-5 [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2005 Feb;5(1):29-35. doi: 10.1007/s11910-005-0020-5.