PMID- 15677875
OWN - NLM
STAT- MEDLINE
DCOM- 20050725
LR  - 20140729
IS  - 1420-4096 (Print)
IS  - 1420-4096 (Linking)
VI  - 28
IP  - 2
DP  - 2005
TI  - Automated impedance cardiography for detecting ischemic left ventricular 
      dysfunction during exercise testing.
PG  - 77-84
AB  - Automated impedance cardiography (ICG) is an attractive method for noninvasive 
      hemodynamic evaluation. The objective of our study was to evaluate the 
      feasibility and diagnostic value automated ICG in patients with suspected 
      coronary artery disease (CAD). We measured stroke index (SI) and cardiac index 
      (CI) in 65 patients with suspected CAD at rest and during bicycle exercise 
      testing. All patients underwent subsequent cardiac catheterization including 
      coronary angiography (CA). Depending on the results of CA, patients were divided 
      into three groups, patients without significant CAD (group 0), single vessel 
      disease (group 1) or multivessel disease (group 2-3). In a subset of 20 patients, 
      automated ICG was compared to measurements of CI by the thermodilution (TD) 
      method. RESULTS: There were no significant differences in SI and CI at baseline 
      between the three groups. At 75- and 100-watt exercise, patients in group 2-3 
      showed significantly lower mean values of SI and CI as compared to patients of 
      group 0 and group 1 (all p < 0.05), indicating exercise-induced ischaemic left 
      ventricular (LV) dysfunction. Three patients had to be excluded because of 
      inappropriate quality of the ICG signals during exercise. Comparison of automated 
      ICG with TD measurements of CI showed good correlations between both methods at 
      rest (r = 0.73) and during exercise (r = 0.89-0.91). CONCLUSIONS: We conclude 
      that hemodynamic monitoring by automated ICG is both feasible and practical 
      during exercise testing. Automated ICG can provide reliable and valuable 
      additional diagnostic information on LV function during exercise which is helpful 
      for selecting those patients for angiography who are likely to benefit from 
      coronary interventions.
FAU - Scherhag, A
AU  - Scherhag A
AD  - I. Medical Clinic, University Hospital Mannheim, Faculty of Clinical Medicine 
      Mannheim, University of Heidelberg, Mannheim, Germany. armin.scherhag@roche.com
FAU - Pfleger, S
AU  - Pfleger S
FAU - Garbsch, E
AU  - Garbsch E
FAU - Buss, J
AU  - Buss J
FAU - Sueselbeck, T
AU  - Sueselbeck T
FAU - Borggrefe, M
AU  - Borggrefe M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20050127
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cardiography, Impedance
MH  - Coronary Artery Disease/diagnosis/physiopathology
MH  - Coronary Circulation
MH  - *Exercise Test
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*diagnosis/physiopathology
MH  - Thermodilution
MH  - Ventricular Dysfunction, Left/*diagnosis/physiopathology
EDAT- 2005/01/29 09:00
MHDA- 2005/07/26 09:00
CRDT- 2005/01/29 09:00
PHST- 2004/12/14 00:00 [accepted]
PHST- 2005/01/29 09:00 [pubmed]
PHST- 2005/07/26 09:00 [medline]
PHST- 2005/01/29 09:00 [entrez]
AID - 83695 [pii]
AID - 10.1159/000083695 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2005;28(2):77-84. doi: 10.1159/000083695. Epub 2005 Jan 
      27.