PMID- 15679072
OWN - NLM
STAT- MEDLINE
DCOM- 20050505
LR  - 20190906
IS  - 0334-018X (Print)
IS  - 0334-018X (Linking)
VI  - 18
IP  - 1
DP  - 2005 Jan
TI  - Serum levels of soluble tumor necrosis factor-alpha receptor 2 are linked to 
      insulin resistance and glucose intolerance in children.
PG  - 75-82
AB  - BACKGROUND: Obesity and insulin resistance are increasingly common problems in 
      children. Tumor necrosis factor-alpha (TNF-alpha) has important effects on lipid 
      and glucose metabolism. This effect may be mediated through soluble TNF-alpha 
      receptor 2 (sTNFR2). OBJECTIVE: To investigate the relationship between insulin 
      resistance and the TNF-alpha system in childhood obesity. CHILDREN AND METHODS: 
      Twenty-one obese and six non-obese children were studied. Body mass index (BMI) 
      z-scores, percent body fat (PBF) and waist to hip ratio (WHR) were determined. 
      Fasting serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, 
      TNF-alpha and sTNFR2 were measured. A standard 2-hour oral glucose tolerance test 
      (dose of glucose: 1.75 g/kg, max. 75 g) was done. Insulin resistance (IR) was 
      estimated by fasting plasma insulin, plasma insulin at 120 min, homeostasis model 
      assessment (HOMA) and insulin area under the curve (AUC) from OGTT. Insulin 
      sensitivity was estimated by oral glucose insulin sensitivity (OGIS120). RESULTS: 
      Among the obese participants, one child (5.2%) was found to have diabetes 
      mellitus and four others (21.1%) impaired glucose tolerance (IGT). Obese children 
      had significantly elevated sTNFR2 levels. Furthermore, the group of obese 
      children with IGT and the patient with newly diagnosed diabetes mellitus together 
      (n = 5) had significantly higher levels of serum sTNFR2 (2,865+/-320 pg/ml) than 
      the rest of the obese (2,460+/-352 pg/ml; p = 0.016) or lean (1,969+/-362 pg/ml; 
      p = 0.014) children. Serum sTNFR2 levels correlated positively with insulin AUC, 
      HOMA IR, fasting plasma insulin, plasma insulin at 120 min, total cholesterol and 
      LDL/ HDL ratio, and negatively with OGIS120. Multiple regression analysis 
      revealed that age, WHR, sTNFR2 and LDL predicted 81% of the variability in 
      glucose at 120 min. CONCLUSION: sTNFR2 is a candidate marker of insulin 
      resistance and glucose intolerance.
FAU - Gupta, Ashutosh
AU  - Gupta A
AD  - Division of Pediatric Endocrinology, Maimonides Medical Center, Brooklyn, NY 
      11219, USA.
FAU - Ten, Svetlana
AU  - Ten S
FAU - Anhalt, Henry
AU  - Anhalt H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Child
MH  - Diabetes Mellitus
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Insulin Resistance
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Male
MH  - Obesity/*physiopathology
MH  - Receptors, Tumor Necrosis Factor
MH  - Receptors, Tumor Necrosis Factor, Type II/*blood
EDAT- 2005/02/01 09:00
MHDA- 2005/05/06 09:00
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/05/06 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - 10.1515/jpem.2005.18.1.75 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2005 Jan;18(1):75-82. doi: 10.1515/jpem.2005.18.1.75.