PMID- 15679728
OWN - NLM
STAT- MEDLINE
DCOM- 20050620
LR  - 20050131
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 60
IP  - 3
DP  - 2005 Mar
TI  - CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of 
      atopic dermatitis in children.
PG  - 391-5
AB  - BACKGROUND: In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and 
      interleukin (IL)-13 seems to play a pivotal role in the inflammatory network. We 
      tried to assess the correlation between the immunological marker CD4(+)IL-13(+) 
      and the clinical phase of extrinsic AD in children. METHODS: Twenty children with 
      AD were studied. Assessed parameters were: clinical severity (SCORAD index), 
      total serum immunoglobulin E (IgE), blood eosinophil count, and percentage of 
      CD4(+)IFNgamma(+), CD4(+)IL-4(+), CD4(+)IL-13(+) T cells. Determinations were 
      carried out in the acute phase and after clinical remission were achieved. Ten 
      nonatopic-matched children served as controls. RESULTS: At baseline, AD was mild 
      in 25%, moderate in 50% and severe in 25% of children. In the acute phase a 
      significant relationship between the eosinophil count and the SCORAD index was 
      found (P = 0.0001). Blood CD4(+)IL-4(+) were significantly higher in the AD group 
      (median 17.0, range: 13.7-21.4) than in controls (12.6, 6.4-17.2, P < 0.0001). 
      CD4(+)IL-13(+) cells in the AD group well correlated (P = 0.0007) with SCORAD 
      index. At remission, a significant correlation between SCORAD index and 
      eosinophil count was found (P < 0.03) and the percentage of CD4(+)IL-13(+) cells 
      globally decreased (P < 0.0001), while no difference was found among SCORAD 
      classes. CONCLUSION: This study confirms the Th2 profile predominance in the 
      peripheral blood of children with AD, and evidences close relationship between 
      the number of CD4(+)IL-13(+) T cells and the disease's severity.
FAU - La Grutta, S
AU  - La Grutta S
AD  - Allergy Unit, Children Hospital -- ARNAS, Palermo, Italy.
FAU - Richiusa, P
AU  - Richiusa P
FAU - Pizzolanti, G
AU  - Pizzolanti G
FAU - Mattina, A
AU  - Mattina A
FAU - Pajno, G B
AU  - Pajno GB
FAU - Citarrella, R
AU  - Citarrella R
FAU - Passalacqua, G
AU  - Passalacqua G
FAU - Giordano, C
AU  - Giordano C
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Interleukin-13)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/*metabolism/pathology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/*physiopathology
MH  - Eosinophils/pathology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-13/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Severity of Illness Index
EDAT- 2005/02/01 09:00
MHDA- 2005/06/21 09:00
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/06/21 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - ALL733 [pii]
AID - 10.1111/j.1398-9995.2005.00733.x [doi]
PST - ppublish
SO  - Allergy. 2005 Mar;60(3):391-5. doi: 10.1111/j.1398-9995.2005.00733.x.