PMID- 15680182
OWN - NLM
STAT- MEDLINE
DCOM- 20050624
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 80
IP  - 2
DP  - 2005 Feb
TI  - Mechanisms underlying anorexia after microinjection of bombesin into the lateral 
      cerebroventricle.
PG  - 289-96
AB  - Intracerebroventricular (i.c.v.) injections of bombesin (BN) and 
      gastrin-releasing peptide (GRP) dose-dependently decreased food intake in male 
      Wistar rats fasted for 17 h. Neuromedin B (NMB) did not show any effect on food 
      intake. After BN administration, locomotor activity did not significantly change, 
      compared with a vehicle-injected group. The anorexia induced by BN (0.3 microg) 
      was perfectly inhibited by pretreatment with a GRP-receptor antagonist, 
      [D-Tyr(6)]BN(6-13) methyl ester (10 microg), an NO synthase inhibitor, 
      L-nitro-arginine (30 microg), and a PKG inhibitor, H-9 (2 microg). The cGMP 
      concentration in the hypothalamus increased 1 h after administration when 
      compared with the vehicle-injected group. On the other hand, an NMB-receptor 
      antagonist, BIM23127 (10 microg), and the protein kinase (PK) C inhibitors, 
      chelerythrine (2 microg) and Go6983 (2 microg), inhibited only the late phase of 
      the anorexia. A PKC activator, phorbol 12, 13-dibutyrate (3 microg), injected 
      into the ventricle decreased food intake. These findings suggest that BN 
      suppresses food intake mainly mediated through the GRP receptor and NO-cGMP-PKG 
      pathway, and NMB receptor and PKC is partly involved in the late phase of the 
      anorexia.
FAU - Tsushima, Hiromi
AU  - Tsushima H
AD  - Department of Cellular and Molecular Pharmacology, Nagoya City University 
      Graduate School of Medical Sciences, Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan. 
      tsushima@med.nagoya-cu.ac.jp
FAU - Mori, Mayumi
AU  - Mori M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041223
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 80043-53-4 (Gastrin-Releasing Peptide)
RN  - PX9AZU7QPK (Bombesin)
SB  - IM
MH  - Animals
MH  - Anorexia/*chemically induced
MH  - Bombesin/*administration & dosage
MH  - Eating/drug effects/physiology
MH  - Gastrin-Releasing Peptide/administration & dosage
MH  - Lateral Ventricles/*drug effects/physiology
MH  - Male
MH  - Microinjections/*methods
MH  - Motor Activity/drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Telencephalon/*drug effects/physiology
EDAT- 2005/02/01 09:00
MHDA- 2005/06/25 09:00
CRDT- 2005/02/01 09:00
PHST- 2004/05/07 00:00 [received]
PHST- 2004/11/26 00:00 [revised]
PHST- 2004/11/29 00:00 [accepted]
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/06/25 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - S0091-3057(04)00388-0 [pii]
AID - 10.1016/j.pbb.2004.11.011 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2005 Feb;80(2):289-96. doi: 10.1016/j.pbb.2004.11.011. 
      Epub 2004 Dec 23.