PMID- 15681129
OWN - NLM
STAT- MEDLINE
DCOM- 20050502
LR  - 20131121
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 27
IP  - 1
DP  - 2005 Jan-Feb
TI  - Effects of prenatal exposure to chronic mild stress and toluene in rats.
PG  - 153-67
AB  - The aim of the present study was to elucidate whether prenatal chronic stress, in 
      combination with exposure to a developmental neurotoxicant, would increase 
      effects in the offspring compared with the effects of either exposure alone. 
      Development and neurobehavioral effects were investigated in female offspring of 
      pregnant rats (Mol:WIST) exposed to chronic mild stress (CMS) during gestational 
      days (GD) 9-20, or 1500 ppm toluene, 6 h/day during gestational days 7-20, or a 
      combination of the two. Prenatal CMS was associated with decreased thymic weight 
      and increased auditory startle response. The corticosterone response to restraint 
      seemed modified by prenatal exposure to toluene. Lactational body weight was 
      decreased in offsprings subjected to CMS, primarily due to effects in the 
      combined exposure group. Cognitive function was investigated in the Morris water 
      maze, and some indications of improved function due to CMS were observed. In the 
      present experimental setting, there was no indication of the two exposures 
      potentiating each other with respect to adverse effects on the nervous system. 
      However, the effects of prenatal CMS indicate that stress during fetal life may 
      interfere with the development of the thymus and increase the reactivity (startle 
      reflex) of the offspring.
FAU - Hougaard, Karin S
AU  - Hougaard KS
AD  - National Institute of Occupational Health, DK-2100 Copenhagen O, Denmark. 
      ksh@ami.dk
FAU - Andersen, Maibritt B
AU  - Andersen MB
FAU - Hansen, Ase M
AU  - Hansen AM
FAU - Hass, Ulla
AU  - Hass U
FAU - Werge, Thomas
AU  - Werge T
FAU - Lund, Soren P
AU  - Lund SP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Dopamine Agonists)
RN  - 0 (Solvents)
RN  - 3FPU23BG52 (Toluene)
RN  - N21FAR7B4S (Apomorphine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Behavior, Animal
MH  - Body Weight/drug effects/physiology
MH  - Cognition/drug effects/physiology
MH  - Corticosterone/blood
MH  - Dopamine Agonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Interactions
MH  - Exploratory Behavior/drug effects/physiology
MH  - Female
MH  - Gestational Age
MH  - Lactation/drug effects/psychology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Neural Inhibition/drug effects/physiology
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Reflex, Acoustic/drug effects/physiology
MH  - Solvents/*toxicity
MH  - Stress, Psychological/*complications
MH  - Toluene/*toxicity
EDAT- 2005/02/01 09:00
MHDA- 2005/05/03 09:00
CRDT- 2005/02/01 09:00
PHST- 2003/11/10 00:00 [received]
PHST- 2004/08/02 00:00 [revised]
PHST- 2004/08/02 00:00 [accepted]
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/05/03 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - S0892-0362(04)00115-1 [pii]
AID - 10.1016/j.ntt.2004.08.001 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2005 Jan-Feb;27(1):153-67. doi: 10.1016/j.ntt.2004.08.001.