PMID- 15681444
OWN - NLM
STAT- MEDLINE
DCOM- 20050809
LR  - 20191210
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 79
IP  - 4
DP  - 2005 Feb
TI  - Differential effects of dengue virus on infected and bystander dendritic cells.
PG  - 2432-9
AB  - Dendritic cells (DCs) play a central role as major targets of dengue virus (DV) 
      infections and initiators of antiviral immune responses. Previous observations 
      showed that DCs are activated by infection, presumably acquiring the capacity to 
      promote cell-mediated immunity. However, separate evaluations of the maturation 
      profiles of infected and uninfected bystander cells show that infection impairs 
      the ability of DCs to upregulate cell surface expression of costimulatory, 
      maturation, and major histocompatibility complex molecules, resulting in reduced 
      T-cell stimulatory capacity. Infected DCs failed to respond to tumor necrosis 
      factor alpha as an additional maturation stimulus and were apoptotic. Interleukin 
      10 (IL-10) was detected in supernatants from cultures of DV-infected DCs and 
      cocultures of DCs and T cells. Taken together, these results constitute an immune 
      evasion strategy used by DV that directly impairs antigen-presenting cell 
      function by maturation blockade and induction of apoptosis.
FAU - Palmer, Dupeh R
AU  - Palmer DR
AD  - Department of Viral Diseases, Walter Reed Army Institute of Research, Naval 
      Research Center, Silver Spring, Maryland, USA.
FAU - Sun, Peifang
AU  - Sun P
FAU - Celluzzi, Christina
AU  - Celluzzi C
FAU - Bisbing, John
AU  - Bisbing J
FAU - Pang, Somnang
AU  - Pang S
FAU - Sun, Wellington
AU  - Sun W
FAU - Marovich, Mary A
AU  - Marovich MA
FAU - Burgess, Timothy
AU  - Burgess T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Chlorocebus aethiops
MH  - Dendritic Cells/immunology/*metabolism/virology
MH  - Dengue Virus/chemistry/*physiology
MH  - Interleukin-10/*metabolism
MH  - Vero Cells
PMC - PMC546567
EDAT- 2005/02/01 09:00
MHDA- 2005/08/10 09:00
PMCR- 2005/02/01
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/08/10 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
PHST- 2005/02/01 00:00 [pmc-release]
AID - 79/4/2432 [pii]
AID - 1554-04 [pii]
AID - 10.1128/JVI.79.4.2432-2439.2005 [doi]
PST - ppublish
SO  - J Virol. 2005 Feb;79(4):2432-9. doi: 10.1128/JVI.79.4.2432-2439.2005.