PMID- 15681746
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20051116
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1029
DP  - 2004 Dec
TI  - Uptake of antigens from the intestine by dendritic cells.
PG  - 75-82
AB  - The intestinal immune system responds to ingested antigens in a variety of ways, 
      ranging from tolerance to full immunity. How T cells are instructed to make these 
      differential responses is still unclear. Dendritic cells (DCs) sample enteric 
      antigens in the lamina propria and Peyer's patches, and transport them within the 
      patch or to mesenteric nodes where they are presented to lymphocytes. It is 
      probable that DCs also transmit information that influences the outcome of T cell 
      activation, but the nature of this information and the factors in the intestine 
      that regulate DC behavior and properties are far from clear. We have developed a 
      model in the rat that permits analysis of DCs actually in the process of 
      migration from the intestine to mesenteric nodes. In this paper we will review 
      those aspects of our research that relate to antigen uptake and discuss these in 
      the context of other experimental systems.
FAU - MacPherson, Gordon
AU  - MacPherson G
AD  - Sir William Dunn School of Pathology, University of Oxford, UK. 
      gordon.macpherson@path.ox.ac.uk
FAU - Milling, Simon
AU  - Milling S
FAU - Yrlid, Ulf
AU  - Yrlid U
FAU - Cousins, Lesley
AU  - Cousins L
FAU - Turnbull, Emma
AU  - Turnbull E
FAU - Huang, Fang-Ping
AU  - Huang FP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antigens)
SB  - IM
MH  - Animals
MH  - Antigens/immunology/metabolism
MH  - Cell Movement/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunity, Mucosal
MH  - Lymph Nodes/immunology
MH  - Peyer's Patches/*immunology
MH  - T-Lymphocytes/immunology
RF  - 60
EDAT- 2005/02/01 09:00
MHDA- 2005/04/22 09:00
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - 1029/1/75 [pii]
AID - 10.1196/annals.1309.010 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2004 Dec;1029:75-82. doi: 10.1196/annals.1309.010.