PMID- 15682049
OWN - NLM
STAT- MEDLINE
DCOM- 20060915
LR  - 20191210
IS  - 0894-7317 (Print)
IS  - 0894-7317 (Linking)
VI  - 18
IP  - 2
DP  - 2005 Feb
TI  - The impaired flow reserve capacity of penetrating intramyocardial coronary 
      arteries in apical hypertrophic cardiomyopathy.
PG  - 128-32
AB  - BACKGROUND: Coronary flow reserve (CFR) capacity of penetrating intramyocardial 
      coronary artery (PICA) in apical hypertrophic (AH) cardiomyopathy has not been 
      studied yet. METHODS: We studied 65 patients with normal coronary angiogram 
      results (mean age 56 +/- 10 years; 33 men, 32 women). Of these, 30 were 
      normotensive without any left ventricular hypertrophy (control group), 24 had 
      hypertension (HTN) without any left ventricular hypertrophy (HTN group), and 11 
      had AH cardiomyopathy (AH group). PICA-CFR and PICA-width ratio were calculated 
      after the intravenous infusion of adenosine (140 microg/kg/min) just beneath the 
      apical impulse window at a depth of 3 to 5 cm by using high-frequency 
      transthoracic Doppler echocardiography. RESULTS: PICA-CFR was successfully 
      measured in 59 (90.8%) of 65 patients. PICA-CFR was 1.65 +/- 0.49 in AH group, 
      2.50 +/- 0.77 in HTN group, and 2.42 +/- 0.73 in control group ( P < .005 vs HTN 
      and control). PICA-width ratio was 1.45 +/- 0.42 in AH group, 2.14 +/- 0.72 in 
      HTN group, and 1.81 +/- 0.55 in control group ( P = .025 vs HTN and control). 
      PICA-CFR was closely related to width-ratio of PICA ( r = 0.448, P = .002). 
      Conclusion PICA in AH has higher resting diastolic velocity, wider diameter, and 
      impaired CFR compared with nonhypertrophied myocardium.
FAU - Youn, Ho-Joong
AU  - Youn HJ
AD  - Department of Internal Medicine, College of Medicine, The Catholic University of 
      Korea, No. 62 Yoido-dong, Young-dungpo-ku, St. Mary's Hospital, Seoul 150-713, 
      Korea. younhj@catholic.ac.kr
FAU - Lee, Jong-Min
AU  - Lee JM
FAU - Park, Chul-Soo
AU  - Park CS
FAU - Ihm, Sang-Hyun
AU  - Ihm SH
FAU - Cho, Eun-Joo
AU  - Cho EJ
FAU - Jung, Hae-Ok
AU  - Jung HO
FAU - Jeon, Hui-Kyung
AU  - Jeon HK
FAU - Oh, Yong-Seog
AU  - Oh YS
FAU - Chung, Wook-Sung
AU  - Chung WS
FAU - Kim, Jae-Hyung
AU  - Kim JH
FAU - Choi, Kyu-Bo
AU  - Choi KB
FAU - Hong, Soon-Jo
AU  - Hong SJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
CIN - J Am Soc Echocardiogr. 2005 Dec;18(12):1464-6. PMID: 16376783
MH  - Adult
MH  - Aged
MH  - Blood Flow Velocity
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - Coronary Angiography
MH  - *Coronary Circulation
MH  - Coronary Vessels/diagnostic imaging/*physiopathology
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Hypertension/diagnostic imaging/physiopathology
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocardium/pathology
MH  - Observer Variation
MH  - Prospective Studies
EDAT- 2005/02/01 09:00
MHDA- 2006/09/16 09:00
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2006/09/16 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - S0894731704007783 [pii]
AID - 10.1016/j.echo.2004.08.043 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2005 Feb;18(2):128-32. doi: 10.1016/j.echo.2004.08.043.