PMID- 15682432
OWN - NLM
STAT- MEDLINE
DCOM- 20050302
LR  - 20171116
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 205
IP  - 3
DP  - 2005 Feb
TI  - FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary 
      cutaneous marginal zone lymphoma.
PG  - 302-10
AB  - Primary cutaneous marginal zone lymphomas (PCMZL) share histological and clinical 
      characteristics with mucosa-associated lymphoid tissue (MALT) lymphomas 
      suggesting a common pathogenesis. A number of recurrent structural and numerical 
      chromosomal aberrations have been described in MALT lymphoma, but their incidence 
      in PCMZL is largely unknown, as is their relation with clinical and pathological 
      data. In this study, the incidence of t(11;18)(q21;q21), t(1;14)(p22;q32), two 
      different t(14;18)(q32;q21), involving either IGH/MALT1 or IGH/BCL2, and 
      numerical aberrations of chromosomes 3, 7, 12 and 18 were analysed in 12 patients 
      with PCMZL, with follow-up of up to 10 years. Nuclei were isolated from paraffin 
      wax sections for dual-colour interphase fluorescence in situ hybridization (FISH) 
      using various probe sets either flanking or spanning the involved genes. 
      T(14;18)(q32;q21), with breakpoints in IGH and MALT1, was found in three cases. 
      All three had partly monocytoid histological appearances and lacked blastic 
      transformation. An additional trisomy of chromosome 3 was detected in one of 
      these cases. Trisomy 18 was present in two lymphomas without monocytoid 
      morphology. No definite correlation was seen with any clinical feature, including 
      Borrelia serology. Neither t(11;18)(q21;q21), nor t(1;14)(p22;q32) or any other 
      translocation involving IGH, BCL10, MALT1, BCL2 and API2, amplification or 
      deletion of chromosomal region 11q21, 18q21, 1p22, and 14q32 was detected. These 
      results indicate that a subgroup of PCMZL with partly monocytoid morphology is 
      genetically related to MZL at other extranodal sites.
FAU - Schreuder, M I
AU  - Schreuder MI
AD  - Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The 
      Netherlands.
FAU - Hoefnagel, J J
AU  - Hoefnagel JJ
FAU - Jansen, P M
AU  - Jansen PM
FAU - van Krieken, J H J M
AU  - van Krieken JH
FAU - Willemze, R
AU  - Willemze R
FAU - Hebeda, K M
AU  - Hebeda KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caspases
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics/pathology
MH  - Lymphoma, B-Cell, Marginal Zone/genetics
MH  - Male
MH  - Middle Aged
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/genetics
MH  - Prognosis
MH  - Skin Neoplasms/*genetics/pathology
MH  - *Translocation, Genetic
MH  - *Trisomy
EDAT- 2005/02/01 09:00
MHDA- 2005/03/03 09:00
CRDT- 2005/02/01 09:00
PHST- 2005/02/01 09:00 [pubmed]
PHST- 2005/03/03 09:00 [medline]
PHST- 2005/02/01 09:00 [entrez]
AID - 10.1002/path.1711 [doi]
PST - ppublish
SO  - J Pathol. 2005 Feb;205(3):302-10. doi: 10.1002/path.1711.