PMID- 15682828
OWN - NLM
STAT- MEDLINE
DCOM- 20050222
LR  - 20190922
IS  - 0023-5679 (Print)
IS  - 0023-5679 (Linking)
VI  - 51
IP  - 3-4
DP  - 2004
TI  - Immunohistochemical expression of matrix metalloproteinases in bile duct cancer 
      tissue.
PG  - 215-23
AB  - In the present study we have examined the immunohistochemical expression of 
      matrix metalloproteinases (MMPs) in bile duct cancer tissue and the relationship 
      between MMP expression and various clinicopathologic factors. We performed 
      immunohistochemical studies of matrix metalloproteinase-2 (MMP2), and matrix 
      metalloproteinase-3 (MMP3). MMP2 and MMP3 were expressed in 48.9% (23/47) and 
      44.7% (21/47) of the subjects, respectively. Subjects positive for MMP2 showed 
      significantly higher association rates of MMP3 expression than those who were not 
      (p<0.05). MMP2 expression was also significantly higher in the group with 
      histologically well-differentiated lesions than in the group with poorly 
      differentiated lesions (p<0.05). Expression of MM2 and MM3 was significantly 
      higher in subjects with neural invasion (p<0.05). The MMP2-negative group had a 
      significantly better prognosis than the MMP2-positive group (p<0.05). MMP2 
      expression tended to increase as the degree of differentiation decreased, and 
      this indicated a possibility that MMP2 and MMP3 may be involved in the 
      development of perineural invasion in bile duct cancer. Perineural invasion is an 
      important prognostic factor in bile duct cancer, and the fact that various types 
      of cytokines are involved in the activation of MMPs suggested that bile duct 
      cancer complicated by obstructive cholangitis might be associated with a poorer 
      prognosis.
FAU - Sakai, Takenori
AU  - Sakai T
AD  - Department of Surgery, Kurume University School of Medicine, Kurume 830-0011, 
      Japan. takenori1966@r4.dion.ne.jp
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Kurume Med J
JT  - The Kurume medical journal
JID - 2985210R
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bile Duct Neoplasms/*enzymology/mortality/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Matrix Metalloproteinase 2/*analysis
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Middle Aged
MH  - Prognosis
MH  - Survival Rate
EDAT- 2005/02/03 09:00
MHDA- 2005/02/23 09:00
CRDT- 2005/02/03 09:00
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/02/23 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - 10.2739/kurumemedj.51.215 [doi]
PST - ppublish
SO  - Kurume Med J. 2004;51(3-4):215-23. doi: 10.2739/kurumemedj.51.215.