PMID- 15683420
OWN - NLM
STAT- MEDLINE
DCOM- 20050719
LR  - 20061115
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 20
IP  - 2
DP  - 2005 Feb
TI  - Human leukocyte antigen allele associations in type-1 autoimmune hepatitis 
      patients from western India.
PG  - 193-7
AB  - BACKGROUND AND AIMS: The immunogenetic basis of autoimmune diseases has become 
      more and more evident. We have analyzed the human leukocyte antigen (HLA) 
      associations with type-1 autoimmune hepatitis (AIH) among patients from western 
      India. METHODS: In 20 patients and 120 healthy controls, polymerase chain 
      reaction amplified with sequence specific primers and hybridized with oligoprobes 
      was carried out to elucidate the HLA A, B, C and DRB1 allele associations. 
      RESULTS: The study revealed that A*0222 (20% vs 1.66%; P = 0.0001), A*3201 (15% 
      vs 0.83%; P = 0.0004), A*680102 (30% vs 6.66%; P = 0.001), B*35 (40% vs 11.66%; P 
      = 0.001), B*5501 (10% vs 0.83%; P = 0.008), Cw*0102 (15% vs 1.66%; P = 0.002) and 
      Cw*070101 (50% vs 11.66%; P = 2.5E-05) were significantly increased among the A, 
      B and C alleles of AIH patients. Among the HLA DRB1 alleles, DRB1*0301 (20% vs 
      6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 
      0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when 
      compared with the controls. CONCLUSIONS: The present study indicates that the HLA 
      susceptibility to type 1 AIH in the different populations studied is complex.
CI  - (c) 2004 Blackwell Publishing Asia Pty Ltd.
FAU - Shankarkumar, Umapathy
AU  - Shankarkumar U
AD  - HLA Department, Institute of Immunohaematology (ICMR), KEM Hospital, Parel, 
      Mumbai 400-012, Maharashtra, India. shankarkumar16@hotmail.com
FAU - Amarapurkar, Deepak N
AU  - Amarapurkar DN
FAU - Kankonkar, Sharada
AU  - Kankonkar S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*analysis
MH  - Hepatitis, Autoimmune/epidemiology/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Male
EDAT- 2005/02/03 09:00
MHDA- 2005/07/20 09:00
CRDT- 2005/02/03 09:00
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/07/20 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - JGH3608 [pii]
AID - 10.1111/j.1440-1746.2004.03608.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2005 Feb;20(2):193-7. doi: 
      10.1111/j.1440-1746.2004.03608.x.