PMID- 15683487
OWN - NLM
STAT- MEDLINE
DCOM- 20050603
LR  - 20131121
IS  - 0147-8389 (Print)
IS  - 0147-8389 (Linking)
VI  - 28 Suppl 1
DP  - 2005 Jan
TI  - Edrophonium-induced right ventricular outflow tract tachycardia.
PG  - S158-62
AB  - Idiopathic right ventricular outflow tract-ventricular tachycardia (RVOT-VT) 
      generally occurs when sympathetic nervous system activity is increased, though, 
      in a few patients, it develops when parasympathetic nervous activity (PNA) is 
      increased. Among 101 consecutive patients with RVOT-VT confirmed by endocardial 
      catheter mapping, 5 (4.9%) presented with nocturnal RVOT-VT. Autonomic nervous 
      balance was studied by heart rate variability (HRV) analysis from 24-hour 
      ambulatory electrocardiogram (ECG). Standard programmed ventricular stimulation 
      (PVS), ventricular burst pacing, and drug provocation were performed to induce 
      RVOT-VT. In the studied five patients, the average number of mostly nocturnal 
      ventricular premature contractions (VPCs) was 6649 +/- 4472/day. Two patients had 
      nocturnal nonsustained RVOT-VT on 24-hour ambulatory ECG recordings. The HRV 
      analysis revealed that a progressive increase in high-frequency power coincided 
      with an increase in VPCs or development of RVOT-VT at night, whereas low/high 
      frequency ratio did not change significantly during the 24-hour period. RVOT-VT 
      could not be induced by PVS, ventricular burst pacing, or isoproterenol or 
      adenosine triphosphate i.v. However, RVOT-VT could only be induced by 
      edrophonium, 5 mg i.v., in all patients. An increase in PNA was observed in a few 
      patients before the development of RVOT-VT. Edrophonium facilitated induction of 
      RVOT-VT in such patients.
FAU - Hachiya, Hitoshi
AU  - Hachiya H
AD  - Cardiology Department, Yokosuka Kyosai General Hospital, Kanagawa, Japan.
FAU - Aonuma, Kazutaka
AU  - Aonuma K
FAU - Yamauchi, Yasuteru
AU  - Yamauchi Y
FAU - Sekiguchi, Yukio
AU  - Sekiguchi Y
FAU - Iesaka, Yoshito
AU  - Iesaka Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
RN  - 0 (Cholinesterase Inhibitors)
RN  - 70FP3JLY7N (Edrophonium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cholinesterase Inhibitors/*adverse effects
MH  - Edrophonium/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tachycardia, Ventricular/*chemically induced/physiopathology
EDAT- 2005/02/03 09:00
MHDA- 2005/06/04 09:00
CRDT- 2005/02/03 09:00
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/06/04 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - PACE007 [pii]
AID - 10.1111/j.1540-8159.2005.00007.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2005 Jan;28 Suppl 1:S158-62. doi: 
      10.1111/j.1540-8159.2005.00007.x.