PMID- 15687046
OWN - NLM
STAT- MEDLINE
DCOM- 20050520
LR  - 20181113
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 113
IP  - 2
DP  - 2005 Feb
TI  - Exposure to PCBs and p,p'-DDE and human sperm chromatin integrity.
PG  - 175-9
AB  - Persistent organochlorine pollutants (POPs) such as polychlorinated biphenyls 
      (PCBs) and dichlorodiphenyldichloroethylene (p,p'-DDE), the major metabolite of 
      dichlorodiphenyltrichloroethane (DDT), are stable lipophilic compounds widely 
      found in the environment and in the general population. They can enter the food 
      chain, and their negative impact on male reproduction is currently under active 
      scrutiny. To explore the hypothesis that environmental exposure to these 
      compounds is associated with altered sperm chromatin structure integrity in human 
      sperm, we conducted a study of 176 Swedish fishermen (with low and high 
      consumption of fatty fish, a very important exposure source of POPs). We 
      determined serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 
      p,p'-DDE, and we used the sperm chromatin structure assay (SCSA) to assess sperm 
      DNA/chromatin integrity. When CB-153 serum levels (individual dose range, 
      39-1,460 ng/g lipid) were categorized into equally sized quintiles, we found an 
      association with the DNA fragmentation index (%DFI). A significantly lower %DFI 
      was found in the lowest CB-153 quintile (< 113 ng/g lipid) compared with the 
      other quintiles; there was a similar tendency, although not statistically 
      significant, between %DFI and p,p'-DDE. These results suggest that POP exposure 
      may have a slight negative impact on human sperm chromatin integrity.
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
AD  - Department of Occupational and Environmental Medicine, Lund University Hospital, 
      Lund, Sweden. Anna.Rignell-Hydbom@ymed.lu.se
FAU - Rylander, Lars
AU  - Rylander L
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Jonsson, B A G
AU  - Jonsson BA
FAU - Lindh, Christian
AU  - Lindh C
FAU - Eleuteri, Patrizia
AU  - Eleuteri P
FAU - Rescia, Michele
AU  - Rescia M
FAU - Leter, Giorgio
AU  - Leter G
FAU - Cordelli, Eugenia
AU  - Cordelli E
FAU - Spano, Marcello
AU  - Spano M
FAU - Hagmar, Lars
AU  - Hagmar L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Chromatin)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromatin/drug effects
MH  - *DNA Damage
MH  - Dichlorodiphenyl Dichloroethylene/blood/*toxicity
MH  - Environmental Monitoring
MH  - Environmental Pollutants/blood/*toxicity
MH  - Flow Cytometry
MH  - Humans
MH  - Lipids/analysis
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Spermatozoa/*drug effects
MH  - Sweden
PMC - PMC1277861
EDAT- 2005/02/03 09:00
MHDA- 2005/05/21 09:00
PMCR- 2005/02/01
CRDT- 2005/02/03 09:00
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/05/21 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
PHST- 2005/02/01 00:00 [pmc-release]
AID - ehp0113-000175 [pii]
AID - 10.1289/ehp.7252 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2005 Feb;113(2):175-9. doi: 10.1289/ehp.7252.