PMID- 15688085
OWN - NLM
STAT- MEDLINE
DCOM- 20050809
LR  - 20150311
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 30
IP  - 7
DP  - 2005 Jul
TI  - Elevation of ambient room temperature has differential effects on MDMA-induced 
      5-HT and dopamine release in striatum and nucleus accumbens of rats.
PG  - 1312-23
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) produces acute dopamine and 5-HT release 
      in rat brain and a hyperthermic response, which is dependent on the ambient room 
      temperature in which the animal is housed. We examined the effect of ambient room 
      temperature (20 and 30 degrees C) on MDMA-induced dopamine and 5-HT efflux in the 
      striatum and shell of nucleus accumbens (NAc) of freely moving rats by using 
      microdialysis. Locomotor activity and rectal temperature were also evaluated. In 
      the NAc, MDMA (2.5 or 5 mg/kg, i.p.) produced a substantial increase in 
      extracellular dopamine, which was more marked at 30 degrees C. 5-HT release was 
      also increased by MDMA given at 30 degrees C. In contrast, MDMA-induced 
      extracellular dopamine and 5-HT increases in the striatum were unaffected by 
      ambient temperature. At 20 degrees C room temperature, MDMA did not modify the 
      rectal temperature but at 30 degrees C it produced a rapid and sustained 
      hyperthermia. MDMA at 20 degrees C room temperature produced a two-fold increase 
      in activity compared with saline-treated controls. The MDMA-induced increase in 
      locomotor activity was more marked at 30 degrees C due to a decrease in the 
      activity of the saline-treated controls at this high ambient temperature. These 
      results show that high ambient temperature enhances MDMA-induced locomotor 
      activity and monoamine release in the shell of NAc, a region involved in the 
      incentive motivational properties of drugs of abuse, and suggest that the 
      rewarding effects of MDMA may be more pronounced at high ambient temperature.
FAU - O'Shea, Esther
AU  - O'Shea E
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, 
      Madrid, Spain.
FAU - Escobedo, Isabel
AU  - Escobedo I
FAU - Orio, Laura
AU  - Orio L
FAU - Sanchez, Veronica
AU  - Sanchez V
FAU - Navarro, Miguel
AU  - Navarro M
FAU - Green, A Richard
AU  - Green AR
FAU - Colado, M Isabel
AU  - Colado MI
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Serotonin Agents)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Body Temperature/physiology
MH  - Brain Chemistry
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Microdialysis/methods
MH  - Motor Activity/drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/metabolism/*pharmacology
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Rats
MH  - Serotonin/*metabolism
MH  - Serotonin Agents/*pharmacology
MH  - Temperature
MH  - Time Factors
EDAT- 2005/02/03 09:00
MHDA- 2005/08/10 09:00
CRDT- 2005/02/03 09:00
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/08/10 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - 1300673 [pii]
AID - 10.1038/sj.npp.1300673 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2005 Jul;30(7):1312-23. doi: 10.1038/sj.npp.1300673.