PMID- 15688282
OWN - NLM
STAT- MEDLINE
DCOM- 20050324
LR  - 20071114
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 191
IP  - 5
DP  - 2005 Mar 1
TI  - T cell activation in HIV-seropositive Ugandans: differential associations with 
      viral load, CD4+ T cell depletion, and coinfection.
PG  - 694-701
AB  - Immune activation is thought to play a major role in the pathogenesis of human 
      immunodeficiency virus (HIV). This effect may be particularly relevant in Africa, 
      where endemic coinfections may contribute to disease progression, perhaps as a 
      consequence of enhanced immune activation. We investigated the expression of CD38 
      and human leukocyte antigen (HLA)-DR on T cells in 168 HIV-seropositive 
      volunteers in Uganda. We observed higher levels of CD4(+) and CD8(+) T cell 
      activation in Uganda, compared with those reported in previous studies from 
      Western countries. Coexpression of CD38 and HLA-DR on both CD4(+) and CD8(+) T 
      cell subsets was directly correlated with viral load and inversely correlated 
      with CD4(+) T cell counts. In antiretroviral therapy (ART)-naive volunteers, 
      viral load and CD4(+) T cell count had stronger associations with CD8(+) and 
      CD4(+) T cell activation, respectively. Virus suppression by ART was associated 
      with a reduction in T cell activation, with a stronger observed effect on 
      reducing CD8(+) compared with CD4(+) T cell activation. The presence of 
      coinfection was associated with increased CD4(+) T cell activation but, 
      interestingly, not with increased CD8(+) T cell activation. Our results suggest 
      that distinct mechanisms differentially drive activation in CD4(+) and CD8(+) T 
      cell subsets, which may impact the clinical prognostic values of T cell 
      activation in HIV infection.
FAU - Eggena, Mark P
AU  - Eggena MP
AD  - University of California, San Francisco, California, USA. 
      eggena@medicine.ucsf.edu
FAU - Barugahare, Banson
AU  - Barugahare B
FAU - Okello, Martin
AU  - Okello M
FAU - Mutyala, Steven
AU  - Mutyala S
FAU - Jones, Norman
AU  - Jones N
FAU - Ma, Yifei
AU  - Ma Y
FAU - Kityo, Cissy
AU  - Kityo C
FAU - Mugyenyi, Peter
AU  - Mugyenyi P
FAU - Cao, Huyen
AU  - Cao H
LA  - eng
GR  - AI054366/AI/NIAID NIH HHS/United States
GR  - AI4374/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050131
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Retroviral Agents/therapeutic use
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/complications/drug therapy/*immunology/virology
MH  - HIV Seropositivity/immunology
MH  - Humans
MH  - Logistic Models
MH  - Lymphocyte Activation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Uganda
MH  - *Viral Load
EDAT- 2005/02/03 09:00
MHDA- 2005/03/25 09:00
CRDT- 2005/02/03 09:00
PHST- 2004/07/09 00:00 [received]
PHST- 2004/09/03 00:00 [accepted]
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/03/25 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - JID33318 [pii]
AID - 10.1086/427516 [doi]
PST - ppublish
SO  - J Infect Dis. 2005 Mar 1;191(5):694-701. doi: 10.1086/427516. Epub 2005 Jan 31.