PMID- 15688285
OWN - NLM
STAT- MEDLINE
DCOM- 20050324
LR  - 20061115
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 191
IP  - 5
DP  - 2005 Mar 1
TI  - Etiology of mumps-like illnesses in children and adolescents vaccinated for 
      measles, mumps, and rubella.
PG  - 719-23
AB  - The possible viral etiology of mumps-like illnesses in patients vaccinated for 
      measles, mumps, and rubella (MMR) was studied by use of serum samples 
      prospectively collected, during 1983-1998, from 601 acutely ill Finnish children 
      and adolescents with mumps-like symptoms. Mumps virus was excluded by testing 
      serum samples for mumps antibodies, and the serum samples were further tested for 
      antibodies to adenovirus, enterovirus, Epstein-Barr virus, parainfluenza virus 
      types 1-3, and parvovirus B19. The serum samples of 114 children <4 years old 
      were also tested for antibodies to human herpesvirus 6 (HHV-6). A viral etiology 
      was verified in 84 cases (14%), most commonly Epstein-Barr virus (7%), followed 
      by parainfluenza virus types 1, 2, or 3 (4%) and adenovirus (3%). HHV-6 infection 
      was found in 5 children <4 years old (4%). This study confirms that mumps-like 
      symptoms in MMR-vaccinated children and adolescents are often not caused by mumps 
      virus infection. Careful laboratory-based diagnostic testing of MMR-vaccinated 
      children and adolescents who develop clinical symptoms compatible with those of 
      mumps is important in the treatment of individual patients, in the comprehension 
      of the true epidemiology of these illnesses, and in the evaluation of the impact 
      of MMR vaccination programs.
FAU - Davidkin, Irja
AU  - Davidkin I
AD  - National Public Health Institute, Helsinki, Finland. irja.davidkin@ktl.fi
FAU - Jokinen, Sari
AU  - Jokinen S
FAU - Paananen, Anja
AU  - Paananen A
FAU - Leinikki, Pauli
AU  - Leinikki P
FAU - Peltola, Heikki
AU  - Peltola H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050119
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Measles-Mumps-Rubella Vaccine)
SB  - IM
MH  - Adenoviridae Infections/diagnosis
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Enterovirus Infections/diagnosis
MH  - Epstein-Barr Virus Infections/diagnosis
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Measles-Mumps-Rubella Vaccine
MH  - Paramyxoviridae Infections/diagnosis
MH  - Parotitis/*virology
MH  - Parvoviridae Infections/diagnosis
MH  - Roseolovirus Infections/diagnosis
MH  - Seasons
MH  - Virus Diseases/*diagnosis/epidemiology
EDAT- 2005/02/03 09:00
MHDA- 2005/03/25 09:00
CRDT- 2005/02/03 09:00
PHST- 2003/12/31 00:00 [received]
PHST- 2004/09/07 00:00 [accepted]
PHST- 2005/02/03 09:00 [pubmed]
PHST- 2005/03/25 09:00 [medline]
PHST- 2005/02/03 09:00 [entrez]
AID - JID32299 [pii]
AID - 10.1086/427338 [doi]
PST - ppublish
SO  - J Infect Dis. 2005 Mar 1;191(5):719-23. doi: 10.1086/427338. Epub 2005 Jan 19.