PMID- 15691311
OWN - NLM
STAT- MEDLINE
DCOM- 20050428
LR  - 20111117
IS  - 1083-4389 (Print)
IS  - 1083-4389 (Linking)
VI  - 10
IP  - 1
DP  - 2005 Feb
TI  - Association of Helicobacter pylori-related distal gastric cancer with the HLA 
      class II gene DQB10602 and cagA strains in a southern European population.
PG  - 12-21
AB  - BACKGROUND: Distinct human leukocyte antigen (HLA)-DQ genes have been associated 
      with an increased or reduced risk for gastric cancer, but its association with 
      Helicobacter pylori status is controversial. In the present study we evaluated 
      the influence of host HLA DQA1 and DQB1 loci, H. pylori genotype, and 
      socio-economic factors on predicting H. pylori-associated distal gastric cancer 
      in a southern European population. MATERIAL AND METHODS: In a prospective 
      case-control (1 : 2) study, 42 patients with H. pylori-associated distal gastric 
      cancer were matched by age (+/-5 years) and gender to 84 patients with H. 
      pylori-associated benign gastroduodenal disease (controls). The level of 
      education received, smoking status, alcohol consumption, origin and familial 
      history of gastric cancer were registered at inclusion. HLA DQA1 and DQB1 typing 
      and H. pylori genotyping were determined from endoscopic gastric mucosal 
      biopsies. RESULTS: Compared with control patients, a positive association with 
      cagA(+) strains (p < .002) and a negative association with vacA-s2 strains (p < 
      .02) was found in patients with distal gastric cancer. At the DQB1 locus, the 
      (*)0602 allele was more frequent in distal gastric cancer than in controls (26.2% 
      vs. 4.8%; p < .005). After correction for multiple comparisons (exact multiple 
      regression analysis) the cagA(+) status and the DQB1(*)0602 allele were 
      associated with an increased distal gastric cancer risk (OR 3.7; 95% CI = 
      1.33-12.26 and OR 4.82; 95% CI = 1.24-19.83, respectively) whereas the vacA-s2 
      status was associated with a decreased risk (OR 0.33; 95% CI = 0.10-0.94). 
      CONCLUSION: Our findings suggest that in the H. pylori-infected southern European 
      population, the cagA genotype and the HLA-DQB1(*)0602 gene confer an increased 
      risk for distal gastric cancer.
FAU - Quintero, Enrique
AU  - Quintero E
AD  - Gastroenterology Department, University Hospital of the Canary Islands, Spain. 
      equinter@doymanet.es
FAU - Pizarro, M Angeles
AU  - Pizarro MA
FAU - Rodrigo, Luis
AU  - Rodrigo L
FAU - Pique, Josep M
AU  - Pique JM
FAU - Lanas, Angel
AU  - Lanas A
FAU - Ponce, Julio
AU  - Ponce J
FAU - Mino, Gonzalo
AU  - Mino G
FAU - Gisbert, Javier
AU  - Gisbert J
FAU - Jurado, Aurora
AU  - Jurado A
FAU - Herrero, M Jose
AU  - Herrero MJ
FAU - Jimenez, Alejandro
AU  - Jimenez A
FAU - Torrado, Julio
AU  - Torrado J
FAU - Ponte, Ana
AU  - Ponte A
FAU - Diaz-de-Rojas, Francisco
AU  - Diaz-de-Rojas F
FAU - Salido, Eduardo
AU  - Salido E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (cagA protein, Helicobacter pylori)
SB  - IM
MH  - Aged
MH  - Antigens, Bacterial/analysis/*genetics
MH  - Bacterial Proteins/analysis/*genetics
MH  - Case-Control Studies
MH  - Europe
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Helicobacter Infections/*complications
MH  - Helicobacter pylori/*genetics/isolation & purification
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Risk Factors
MH  - Stomach Neoplasms/epidemiology/*genetics/*microbiology
EDAT- 2005/02/05 09:00
MHDA- 2005/04/29 09:00
CRDT- 2005/02/05 09:00
PHST- 2005/02/05 09:00 [pubmed]
PHST- 2005/04/29 09:00 [medline]
PHST- 2005/02/05 09:00 [entrez]
AID - HEL287 [pii]
AID - 10.1111/j.1523-5378.2005.00287.x [doi]
PST - ppublish
SO  - Helicobacter. 2005 Feb;10(1):12-21. doi: 10.1111/j.1523-5378.2005.00287.x.